The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH₃COO)Cl₂(NH₃)₂(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

Table 1

Lipophilicity (HPLC log k′ measured on a C₁₈ column and log measured on the immobilized artificial membrane column), polar surface area (PSA), half-life (t_½ at 37°C in the presence of a ten-fold excess of ascorbic acid), and reduction peak potential (E_p, V vs. Ag/AgCl, 3M KCl, glassy carbon electrode, and the scan rate 0.2 V·s⁻¹) for Complexes 1–3.

Compounds	Log k′	Log	PSA (Å^2)	Ep (V)^a	t½ (min)^a
1	−1.50	−1.06	116	−0.815	8.6
2	−1.10	−0.96	112	−0.618	20.5
3	−0.84	−0.83	110	−0.486	528

^a from [25].