Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice

Figure 3

Antimalarial activity of DFP-RVT, DFP, and PYR in PbANKA-infected mice. The PbANKA-infected mice were orally administered with 60% DMSO, PYR (2 mg/kg BW), DFP (50 mg/kg BW), and DFP-RVT (50 mg/kg BW) everyday for 8 consecutive days. The percentage of pRBC was determined using the microscopic Giemsa staining method and presented as either % parasitemia (a) or % suppression (b). Data are expressed as mean ± SEM values. Accordingly, when compared with the uninfected PbANKA group; and , when compared with the infection group treated with DMSO. BW = body weight, DFP = deferiprone, DFP-RVT = deferiprone-resveratrol, DMSO = dimethylsulfoxide, PbANKA = P. berghei ANKA strain, pRBC = parasitized red blood cell, PYR = pyrimethamine, and SEM = standard error of mean values.

(a)

(b)