Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice

Figure 4

BW (a), % BW change (b), liver weight (c), and liver WI (d) of normal mice and PbANKA-infected mice treated with 60% DMSO, DFP-RVT (50 mg/kg BW), DFP (50 mg/kg BW), and PYR (2 mg/kg BW) for 8 consecutive days. Data are expressed as mean ± SEM values (n = 3 each). Accordingly, when compared with the normal group; and when compared with the PbANKA-infected group treated with DMSO. BW = body weight, DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DMSO = dimethylsulfoxide, PbANKA = P. berghei ANKA strain, pRBC = parasitized red blood cell, PYR = pyrimethamine, SEM = standard error of the mean values, and WI = weight index.

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