Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice

Table 1

Hematological parameter levels in normal mice treated with DI and PbANKA-infected mice treated with 60% DMSO, DFP-RVT (50 mg/kg), DFP (50 mg/kg), and PYR (2 mg/kg) (n = 3 each) for 8 consecutive days. Data are expressed as mean ± SEM values. Accordingly, when compared with the normal group; and when compared with the PbANKA-infected group treated with DMSO. (a) RBC indices.

Mice	Treatment	RBC number(×10^6/mL)	Hb (g/dL)	Hct (%)	MCV (fL)	MCH (pg)	MCHC (g/dL)	RDW (%)
Normal	DI	8.86 ± 0.84	13.45 ± 1.25	45.60 ± 6.20	51.10 ± 1.90	15.25 ± 0.25	29.80 ± 1.80	15.55 ± 0.55
PbANKA-infected	DMSO	4.74 ± 0.30^#	8.80 ± 0.65^#	30.00 ± 1.63^#	62.33 ± 1.20^#	18.67 ± 0.33	30.00 ± 0.58	13.33 ± 0.88
PbANKA-infected	PYR	9.66 ± 0.23	16.10 ± 0.40	54.00 ± 2.08	56.00 ± 1.15	16.67 ± 0.33	29.67 ± 0.67	13.67 ± 0.33
PbANKA-infected	DFP	4.57 ± 0.27	8.70 ± 0.33	29.50 ± 0.41	65.00 ± 2.45	19.00 ± 0.58	30.33 ± 0.88	13.67 ± 0.88
PbANKA-infected	DFP-RVT	4.89 ± 0.01	8.50 ± 0.33	26.67 ± 0.67	56.67 ± 2.03	17.67 ± 0.33	31.00 ± 0.58	14.33 ± 0.33

DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DI = deionized water, DMSO = dimethylsulfoxide, Hb = hemoglobin, Hct = hematocrit, MCH = mean corpuscular hemoglobin, MCHC = mean corpuscular hemoglobin concentration, MCV = mean corpuscular volume, PbANKA = Plasmodium berghei ANKA strain, PYR = pyrimethamine, RBC = red blood cell, and RDW = red cell distribution width.