Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice

Table 2

Hematological parameter levels in normal mice treated with DI and PbANKA-infected mice treated with 60% DMSO, DFP-RVT (50 mg/kg), DFP (50 mg/kg), and PYR (2 mg/kg) (n = 3 each) for 8 consecutive days. Data are expressed as mean ± SEM values. Accordingly, when compared with the normal group; and when compared with the PbANKA-infected group treated with DMSO. (b) WBC indices.

Mice	Treatment	WBC number (×10^3/mL	Differential number (%)
			Neutrophil	Lymphocyte	Monocyte	Basophil	Eosinophil
Normal	DI	3.10 ± 0.29	17.00 ± 5.00	80.00 ± 6.00	4.00 ± 0.01	ND	ND
PbANKA-infected	DMSO	16.22 ± 2.10^#	49.67 ± 3.33^#	46.33 ± 3.33^#	2.33 ± 0.33	1.00 ± 0.00	1.00 ± 0.58
PbANKA-infected	PYR	4.05 ± 0.14	35.00 ± 1.63	54.50 ± 3.67	7.67 ± 2.19	1.00 ± 0.00	0.50 ± 0.41
PbANKA-infected	DFP	11.99 ± 2.40	45.00 ± 3.51	51.33 ± 3.67	2.33 ± 0.33	1.00 ± 0.58	0.33 ± 0.33
PbANKA-infected	DFP-RVT	11.10 ± 1.73	46.50 ± 9.39	43.33 ± 9.61	3.00 ± 0.58	0.67 ± 0.33	0.67 ± 0.67

DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DI = deionized water, DMSO = dimethylsulfoxide, ND = not detectable, PbANKA = Plasmodium berghei ANKA strain, and PYR = pyrimethamine.