Deferiprone−Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent in Plasmodium berghei-Infected Mice

Table 3

Levels of AST, ALT, and ALP activities in the plasma of normal mice and PbANKA-infected mice treated with 60% DMSO, DFP (50 mg/kg), DFP-RVT (50 mg/kg), and PYR (2 mg/kg) (n = 3 each) for 8 consecutive days. Data are expressed as mean ± SEM values. Accordingly, when compared with the normal group; and when compared with mice in the PbANKA-infected group that had been treated with DMSO.

Mice	Treatment	Liver enzyme activity
		AST (U/L)	ALT (U/L)	ALP (U/L)
Normal	DI	51.0 ± 1.4	25.6 ± 1.2	25.3 ± 0.4
PbANKA-infected	DMSO	81.7 ± 0.7^#	35.8 ± 2.2	45.8 ± 0.1^#
PbANKA-infected	PYR	68.5 ± 4.0	25.7 ± 3.7	30.0 ± 0.5
PbANKA-infected	DFP	102.8 ± 3.7	36.2 ± 1.1	28.5 ± 0.3
PbANKA-infected	DFP-RVT	80.8 ± 0.1	20.6 ± 0.6	30.5 ± 1.4

ALP = alkaline phosphatase, ALT = alanine aminotransferase, AST = aspartate aminotransferase, DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DI = deionized water, DMSO = dimethylsulfoxide, PbANKA = Plasmodium berghei ANKA strain, and PYR = pyrimethamine.