Comprehensive Assessment of Biomolecular Interactions of Morpholine-Based Mixed Ligand Cu(II) and Zn(II) Complexes of 2,2′-Bipyridine as Potential Anticancer and SARS-CoV-2 Agents: A Synergistic Experimental and Structure-Based Virtual Screening

Table 10

The evaluation of the anticancer properties of ligand (HL) and its complexes (1a-2a) against cancer cell lines and normal cell lines.

Compounds	IC50 (μM)
	A549	HepG2	MCF-7	NHDF
Cisplatin	31.9 ± 1.6	22.9 ± 1.1	20.2 ± 1.0	26.9 ± 1.3
(HL)	126.4 ± 6.3	108.4 ± 5.4	105.2 ± 5.3	208.6 ± 10.4
(1a)	30.8 ± 1.5	33.1 ± 1.7	32.1 ± 1.6	73.6 ± 3.7
(2a)	34.3 ± 1.7	34.6 ± 1.7	35.6 ± 1.8	78.4 ± 3.9