A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η¹-C₂H₄OMe)(DMSO)(phen)]⁺ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells

Figure 2

Representatives 600 MHz ¹H NMR spectra (left panels) and corresponding PCA score plot models (right panels) of SH-SY5Y cells: (a) aqueous extracts (R²X = 0.566; Q² = 0.297); (b) lipid extracts (R²X = 0.946; Q² = 0.913); and (c) growth media (R²X = 0.879; Q² = 0.851). Iso: isoleucine, leu: leucine, val: valine, but: butyrate, lac: lactate, thr: threonine, ala: alanine, ace: acetate, glu: glutamate, gln: glutamine, GSH: glutathione, lys: lysine, for: formate, met: methionine, pyr: pyruvate, suc: succinate, cre: creatine, cre-P: creatine phosphate, cho: choline, PC: phosphocholine, GPC: glycerophosphocholine, m-ino: myo-inositol, phe: phenylalanine, tyr: tyrosine, his: histidine, tau: taurine, gly: glycine, ser: serine, UDP-glucose: uridine diphosphate glucose, AXP: adenosine mono- (M), di- (D), triphosphate (T), PTC: phosphatidylcholine, GPL: glycerophospholipids.

(a)

(b)

(c)