A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η¹-C₂H₄OMe)(DMSO)(phen)]⁺ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells

Figure 5

Relevant discriminant metabolites comparison of SH-SY5Y endo-metabolome obtained from different pairwise groups at the different times of treatments: (a) six hours, (b) twelve hours, and (c) twenty-four hours. Blue: Pt-EtOMeSOphen vs. controls; red: cisplatin vs. controls. Metabolites with –Log₂ (FC) negative values have lower concentration compared with controls. Metabolites with –Log₂ (FC) positive values have higher concentration compared with controls. ^∗All the considered FC values have p value < 0.05 except for the cisplatin in panel A in which the FCs have p value > 0.05.

(a)

(b)

(c)