Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives

Table 2

Parameters determined for the binding of 9, 10, and 11 with HSA.

Compound	Type of quenching	Equation used	KB × 10^4 (M^−1)	K′B × 10^4 (M^−1)	Log KB	Log K′B
9	Static	3	4.59 ± 0.21	—	4.66 ± 0.04	—
10	Static	3	1.43 ± 0.05	—	4.16 ± 0.03	—
11	“Dynamic” and static	4	3.70 ± 0.33	4.58 ± 0.33	4.57 ± 0.07	4.66 ± 0.07

Conditions: PBS pH 7.4/2% (v/v) DMSO; C_HSA = 3.7 µM for 9 and 5.0 µM for 10 and 11 µM, kept constant; the samples were incubated for 24 h at 37°C.