New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation

<div>Diorganotin complexes induced morphological changes in the MCF7 breast cancer cell line. Giemsa stain of cells incubated with different organotin (IV) complexes concentrations for 48 h. Cell size reduction and rounding (black arrows), cytoplasm vacuolization (<b>2e</b>, box), chromatin condensation and pyknotic nuclei (<b>3e</b>, box), apoptotic bodies (star), cell lysis and necrosis (+). Bar: 20 <i>µ</i>m (20x).</div>

Bioinorganic Chemistry and Applications

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Figure 11

Figure 11: New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation 

Figure 11 | New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation 