New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation
Table 4
IC50 (µM) values of diorganotin complexes 1a–1e, 2a–2e, and 3a–3e, selectivity index (SI), and calculated coefficient (CLogP), and percent inhibition of L1a–L1c at 20 (µM).
Complex
MCF-7
MDA-MB-231
COS-7
SI
CLogP
MCF-7
MDA-MB-231
1a
0.380 ± 0.030
0.12 ± 0.0100
0.49 ± 0.030
1.23
4.9
1.88
1b
8.650 ± 0.700
11.05 ± 1.500
12.17 ± 0.300
1.40
1.10
5.92
1c
0.611 ± 0.020
0.170 ± 0.010
0.68 ± 0.050
1.11
4.00
2.40
1d
0.203 ± 0.008
0.119 ± 0.003
0.18 ± 0.006
0.16
1.51
2.82
1e
0.180 ± 0.005
0.042 ± 0.008
0.14 ± 0.010
0.77
3.33
3.61
2a
0.21 ± 0.040
0.31 ± 0.020
0.62 ± 0.060
2.95
2.00
2.26
2b
1.39 ± 0.030
3.28 ± 0.080
11.58 ± 0.800
8.33
2.53
6.30
2c
1.08 ± 0.010
1.02 ± 0.030
1.15 ± 0.100
1.06
1.13
2.78
2d
0.20 ± 0.002
0.087 ± 0.200
0.28 ± 0.010
1.40
3.21
3.19
2e
0.15 ± 0.020
0.12 ± 0.008
0.29 ± 0.030
1.93
2.41
3.98
3a
0.21 ± 0.009
0.10 ± 0.010
0.34 ± 0.010
1.61
3.40
3.95
3b
0.73 ± 0.100
0.54 ± 0.080
1.60 ± 0.200
2.19
2.96
8.0
3c
0.16 ± 0.010
0.49 ± 0.002
0.25 ± 0.006
1.56
0.51
4.47
3d
0.16 ± 0.006
0.07 ± 0.005
0.16 ± 0.020
1.00
0.30
4.89
3e
0.04 ± 0.002
0.14 ± 0.003
0.25 ± 0.010
6.25
1.79
5.68
Cisplatin
5.30 ± 0.50
27.7 ± −2.90
7.17 ± 0.600
1.35
0.26
Ligand
% Inhibition at 20 (µM)
COS-7
MCF-7
MDA-MB-231
L1a
7.0
NC
NC
L1b
3.6
NC
NC
L1c
48.8
17.6
25.5
Data represent the average of three or four independent assays and are expressed as the mean ± standard error (SE), NC: noncytotoxic at 20 (µM).
