Welding fumes contain metals and other toxic substances known or strongly suspected to be related with oxidative stress and premature cellular senescence. Apolipoprotein J/Clusterin (ApoJ/CLU) is a glycoprotein that is differentially regulated in various physiological and disease states including ageing and age-related diseases. In vitro data showed that exposure of human diploid fibroblasts to hexavalent chromium (Cr(VI)) resulted in premature senescence and significant upregulation of the ApoJ/CLU protein. In this study we analyzed blood and urine samples from shipyard industry welders being exposed to different levels of Cr(VI) over a period of five months in order to assay in vivo the relation of ApoJ/CLU serum levels with Cr(VI). Our findings confirmed the previously reported in vitro data since reduction of Cr levels, after a worksite intervention, associated with lower levels of ApoJ/CLU serum levels. We concluded that the human ApoJ/CLU gene is responsive to the acute in vivo oxidative stress induced by heavy metals such as hexavalent chromium.

Evangelos C. Alexopoulos

Xenophon Cominos

Ioannis P. Trougakos

Magda Lourda

Efstathios S. Gonos

Vassilios Makropoulos

Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders

The N- and C-terminal blocked hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide (LAHYNK) representing the 80&#x2013;85 fragment of histone H2B was synthesized and its interactions with Cu(II) and Ni(II) ions were studied by potentiometric, UV-Vis, CD, EPR, and NMR spectroscopic techniques in solution. Our data reveal that the imidazole N(3) nitrogen atom is the primary ligating group for both metal ions. Sequential amide groups deprotonation and subsequent coordination to metal ions indicated an <svg style="vertical-align:-3.22281pt;width:123.15px;" id="M1" height="14.775" version="1.1" viewBox="0 0 123.15 14.775" width="123.15"  xmlns="http://www.w3.org/2000/svg">
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			<text transform="matrix(1,0,0,-1,20.47,63.45)">
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</svg> coordination mode above <svg style="vertical-align:-2.72116pt;width:46.424999px;" id="M2" height="14.075" version="1.1" viewBox="0 0 46.424999 14.075" width="46.424999"  xmlns="http://www.w3.org/2000/svg">
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				<tspan style="font-size: 12.50px; " x="0" y="0">p</tspan>
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				<tspan style="font-size: 12.50px; " x="18.741997" y="0">∼</tspan>
				<tspan style="font-size: 12.50px; " x="30.782387" y="0">9</tspan>
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</svg>, in all cases. In the case of Cu(II)-peptide system, the almost exclusive formation of the predominant species CuL in neutral media accounting for almost 98&#x25; of the total metal ion concentration at  pH 7.3 strongly indicates that at physiological pH values the sequence -LAHYNK- of histone H2B provides  very efficient binding sites for metal ions. The imidazole pyrrole N(1) ionization (but not coordination) was also detected in species 
CuH<sub  >-4</sub>L present in solution above <svg style="vertical-align:-2.72116pt;width:59.450001px;" id="M3" height="14.075" version="1.1" viewBox="0 0 59.450001 14.075" width="59.450001"  xmlns="http://www.w3.org/2000/svg">
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				<tspan style="font-size: 12.50px; " x="34.945885" y="0">1</tspan>
				<tspan style="font-size: 12.50px; " x="41.197384" y="0">1</tspan>
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</svg>.

Katerina Panagiotou

Maria Panagopoulou

Tilemachos Karavelas

Vassiliki Dokorou

Andrew Hagarman

Jonathan Soffer

Reinhard Schweitzer-Stenner

Gerasimos Malandrinos

Nick Hadjiliadis

Cu(II) and Ni(II) Interactions with the Terminally Blocked Hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide Model of Histone H2B (80&#x02013;85)

A novel tri-<svg style="vertical-align:-0.10033pt;width:7.8874998px;" id="M2" height="7.1374998" version="1.1" viewBox="0 0 7.8874998 7.1374998" width="7.8874998"  xmlns="http://www.w3.org/2000/svg">
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</svg>-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula <svg style="vertical-align:-3.25793pt;width:155.97501px;" id="M3" height="14.75" version="1.1" viewBox="0 0 155.97501 14.75" width="155.97501"  xmlns="http://www.w3.org/2000/svg">
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				<tspan style="font-size: 12.50px; " x="0" y="0">[</tspan>
				<tspan style="font-size: 12.50px; " x="4.1634989" y="0">(</tspan>
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				<tspan style="font-size: 12.50px; " x="13.203168" y="0">(</tspan>
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				<tspan style="font-size: 12.50px; " x="0" y="0">]</tspan>
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</svg> (1) has been synthesized and characterized by elemental analysis and <svg style="vertical-align:-0.17554pt;width:33.662498px;" id="M4" height="13.9875" version="1.1" viewBox="0 0 33.662498 13.9875" width="33.662498"  xmlns="http://www.w3.org/2000/svg">
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				<tspan style="font-size: 8.75px; " x="0" y="0">1</tspan>
				<tspan style="font-size: 8.75px; " x="4.3759999" y="0">1</tspan>
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				<tspan style="font-size: 12.50px; " x="6.9516678" y="0">n</tspan>
			</text>

		</g>
	</g>
</svg>-NMR 
and FT-IR spectroscopic techniques. The crystal structure of 
complex <svg style="vertical-align:-0.0pt;width:7.9375px;" id="M5" height="10.875" version="1.1" viewBox="0 0 7.9375 10.875" width="7.9375"  xmlns="http://www.w3.org/2000/svg">
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		<g transform="translate(72,-63.3)">
			<text transform="matrix(1,0,0,-1,-71.95,63.35)">
				<tspan style="font-size: 12.50px; " x="0" y="0">𝟏</tspan>
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	</g>
</svg>  
has been determined by single crystal X-ray diffraction analysis 
at 120(2)&#x2009;K. The geometry around Sn(IV) is trigonal 
bipyramidal. Three <svg style="vertical-align:-0.10033pt;width:7.8874998px;" id="M6" height="7.1374998" version="1.1" viewBox="0 0 7.8874998 7.1374998" width="7.8874998"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
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			<text transform="matrix(1,0,0,-1,-71.95,66.44)">
				<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
			</text>

		</g>
	</g>
</svg>-butyl 
groups and one oxygen atom from a deprotonated 2-thiobarbituric 
ligand are bonded to the metal center. The geometry is completed 
with one oxygen from a water molecule. Compound <svg style="vertical-align:-0.0pt;width:7.9375px;" id="M7" height="10.875" version="1.1" viewBox="0 0 7.9375 10.875" width="7.9375"  xmlns="http://www.w3.org/2000/svg">
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				<tspan style="font-size: 12.50px; " x="0" y="0">𝟏</tspan>
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	</g>
</svg> exhibits potent, in 
vitro, cytotoxicity against sarcoma cancer cells (mesenchymal 
tissue) from the Wistar rat, polycyclic aromatic hydrocarbons 
(PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhibition 
caused by <svg style="vertical-align:-0.0pt;width:7.9375px;" id="M8" height="10.875" version="1.1" viewBox="0 0 7.9375 10.875" width="7.9375"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.875)">
		<g transform="translate(72,-63.3)">
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				<tspan style="font-size: 12.50px; " x="0" y="0">𝟏</tspan>
			</text>

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	</g>
</svg>, in the rate of 
lipoxygenase (<b  >LOX</b>) catalyzed oxidation 
reaction of linoleic acid to hyperoxolinoleic acid, has been also 
kinetically and theoretically studied. The results are compared to 
that of cisplatin.

Vasilios I. Balas

Sotiris K. Hadjikakou

Nikolaos Kourkoumelis

Mark E. Light

Mike Hursthouse

Apostolos K. Metsios

Spyros Karkabounas

Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri-<svg style="vertical-align:-0.1638pt" height="7.9499998" version="1.1" viewBox="0 0 8.6625004 7.9499998" width="8.6625004" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,7.675)"><path id="x1D45B" d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2&#xA;q42 56 97 103.5t96 71.5q46 26 74 26q9 0 16 -2.5t14 -11.5t9.5 -24.5t-1 -44t-13.5 -68.5q-30 -117 -47 -200q-4 -19 -3.5 -25t6.5 -6q21 0 70 48z" /></g></svg>-Butyltin(IV) with 2-Thiobarbituric Acid

The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to <i>Tetrahymena</i> telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions.

Takashi Murashima

Daichi Sakiyama

Daisuke Miyoshi

Masanori Kuriyama

Takashi Yamada

Toshifumi Miyazawa

Naoki Sugimoto

Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water

A new series of <svg style="vertical-align:-0.0pt;width:33.224998px;" id="M3" height="15.8375" version="1.1" viewBox="0 0 33.224998 15.8375" width="33.224998" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,15.775)"><path id="x5A" d="M561 176l29 -6q-25 -130 -36 -170h-517l-8 15l420 599h-173q-77 0 -102 -7t-39 -29q-19 -29 -35 -87l-29 1q9 111 12 183h24q9 -16 19 -20.5t34 -4.5h399l7 -14l-413 -594q48 -6 163 -6q94 0 131.5 7.5t58.5 29.5q28 29 55 103z" /></g><g transform="matrix(.017,-0,0,-.017,10.534,15.775)"><path id="x6E" d="M524 0h-209v26q44 5 55 18t11 65v167q0 114 -91 114q-50 0 -109 -51v-235q0 -50 10 -61.5t55 -16.5v-26h-217v26q51 5 62 17t11 61v206q0 47 -9.5 58.5t-50.5 19.5v23q82 15 139 40v-79l67 47q47 30 83 30q60 0 94.5 -40t34.5 -112v-193q0 -50 10 -61.5t54 -16.5v-26z&#xA;" /></g><g transform="matrix(.012,-0,0,-.012,19.85,7.613)"><path id="x32" d="M412 140l28 -9q0 -2 -35 -131h-373v23q112 112 161 170q59 70 92 127t33 115q0 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-63t59.5 -17v-26z" /></g><g transform="matrix(.012,-0,0,-.012,16.887,7.613)"><use xlink:href="#x32" /></g><g transform="matrix(.012,-0,0,-.012,22.599,7.613)"><use xlink:href="#x2B" /></g></svg>,  and <svg style="vertical-align:-0.20473pt;width:33.674999px;" id="M7" height="16.1" version="1.1" viewBox="0 0 33.674999 16.1" width="33.674999" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,15.775)"><use xlink:href="#x43" /></g><g transform="matrix(.017,-0,0,-.017,11.605,15.775)"><path id="x6F" d="M257 449q92 0 154 -65t62 -158q0 -112 -67 -175t-150 -63q-98 0 -158.5 66.5t-60.5 154.5q0 59 21 106.5t54.5 75.5t71 43t73.5 15zM244 416q-48 0 -81 -47t-33 -128q0 -96 38 -158t99 -62q51 0 82 43.5t31 139.5q0 91 -36 151.5t-100 60.5z" /></g><g transform="matrix(.012,-0,0,-.012,20.287,7.613)"><use xlink:href="#x32" /></g><g transform="matrix(.012,-0,0,-.012,25.999,7.613)"><use xlink:href="#x2B" /></g></svg> complexes of <svg style="vertical-align:-0.12283pt;width:19.0875px;" id="M8" height="15.9875" version="1.1" viewBox="0 0 19.0875 15.9875" width="19.0875" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,15.775)"><use xlink:href="#x4E" /></g><g transform="matrix(.012,-0,0,-.012,12.687,7.613)"><path id="x31" d="M384 0h-275v27q67 5 81.5 18.5t14.5 68.5v385q0 38 -7.5 47.5t-40.5 10.5l-48 2v24q85 15 178 52v-521q0 -55 14.5 -68.5t82.5 -18.5v-27z" /></g></svg>-methyl-2-(<svg style="vertical-align:-0.0pt;width:21.299999px;" id="M9" height="11.175" version="1.1" viewBox="0 0 21.299999 11.175" width="21.299999" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,11.113)"><use xlink:href="#x31" /></g><g transform="matrix(.017,-0,0,-.017,8.225,11.113)"><use xlink:href="#x48" /></g></svg>-1,2,3-benzotriazol-1-yl)-3-oxobutanethioamide (MBOBT), HL, has been synthesized and characterized by different spectral and  magnetic measurements and elemental analysis. IR spectral data indicates that (MBOBT) exists only in the thione form in the solid state while 
13<svg style="vertical-align:-0.20473pt;width:11.425px;" id="M10" height="11.6875" version="1.1" viewBox="0 0 11.425 11.6875" width="11.425" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,11.363)"><use xlink:href="#x43" /></g></svg> NMR spectrum indicates its existence in thione and thiole tautomeric forms. The IR spectra of all complexes indicate that (MBOBT) acts as a monobasic bidentate ligand coordinating to the metal(II) ions via the keto-oxygen and thiolato-sulphur 
  atoms. The electronic spectral studies showed that (MBOBT) bonded to all metal ions through sulphur and nitrogen atoms based on the positions and intensity of their charge transfer bands. Furthermore, the spectra reflect four coordinate tetrahedral zinc(II),  tetragonally distorted copper(II), square planar nickel(II), 
  and cobalt(II) complexes. Thermal decomposition study of the complexes was monitored by TG and 
  DTG analyses under <svg style="vertical-align:-3.27605pt;width:19.0875px;" id="M11" height="15.25" version="1.1" viewBox="0 0 19.0875 15.25" width="19.0875" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x4E" /></g><g transform="matrix(.012,-0,0,-.012,12.687,15.187)"><use xlink:href="#x32" /></g></svg> atmosphere. The decomposition course and steps were analyzed and the activation parameters of the nonisothermal decomposition are determined. The isolated metal chelates have been screened for their antimicrobial activities and the findings have been reported and discussed in relation to their structures.

Nouria A. Al-Awadi

Nadia M. Shuaib

Alaa Abbas

Ahmed A. El-Sherif

Ali El-Dissouky

Esmaeil Al-Saleh

Synthesis, Characterization, and Biological Activity of <svg style="vertical-align:-0.12283pt" height="16.625" version="1.1" viewBox="0 0 19.325001 16.625" width="19.325001" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,16.413)"><path id="x4E" d="M719 650v-28q-43 -2 -62 -15t-22 -44q-6 -47 -6 -169v-403h-31l-426 524h-2v-251q0 -111 6 -169q4 -37 24 -50.5t72 -16.5v-28h-237v28q45 2 64.5 16t23.5 49q6 62 6 171v220q0 54 -3 68.5t-17 32.5q-16 19 -34.5 26.5t-54.5 10.5v28h147l418 -502h3v246q0 117 -7 166&#xA;q-4 34 -24.5 47t-73.5 15v28h236z" /></g><g transform="matrix(.012,-0,0,-.012,12.687,8.25)"><path id="x1D7CF" d="M441 24v-24h-373v24q75 2 96 20q22 19 22 85v378q0 70 -36 70q-26 0 -65 -16l-20 -8v26l251 109h18v-570q0 -57 19 -75q19 -17 88 -19z" /></g></svg>-Methyl-2-(<svg style="vertical-align:-0.0pt" height="11.825" version="1.1" viewBox="0 0 21.65 11.825" width="21.65" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.017,-0,0,-.017,.062,11.762)"><use xlink:href="#x1D7CF"/></g><g transform="matrix(.017,-0,0,-.017,8.562,11.762)"><path id="x48" d="M729 650v-28q-62 -5 -76 -19.5t-14 -75.5v-404q0 -62 13.5 -76t75.5 -19v-28h-268v28q65 5 79.5 19t14.5 76v199h-341v-199q0 -62 14 -76t76 -19v-28h-263v28q61 5 74.5 19t13.5 76v404q0 62 -14 76t-76 19v28h259v-28q-58 -5 -71 -19t-13 -76v-162h341v162&#xA;q0 61 -13.5 75.5t-72.5 19.5v28h261z" /></g></svg>-1,2,3-Benzotriazol-1-y1)-3-Oxobutan-ethioamide Complexes with Some Divalent Metal (II) Ions

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<p><em>Bioinorganic Chemistry and Applications</em> publishes research in all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry, and applications in fields such as medicine and immunology.</p>


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<p>Chief Editor, Professor Fanizzi, is based at the Università del Salento. His research interests and current projects are related to the study of transition metals (Platinum in particular), coordination organometallic and bioinorganic chemistry, and the applications of high field NMR Spectroscopy.</p>


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Bioinorganic Chemistry and Applications - Table of contents 2008

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Table of Contents 2008 - Page 2 | Bioinorganic Chemistry and Applications | Hindawi

Bioinorganic Chemistry and Applications

Table of Contents

Table of Contents: 2008

Biological Monitoring of Hexavalent Chromium and Serum Levels of the Senescence Biomarker Apolipoprotein J/Clusterin in Welders

Cu(II) and Ni(II) Interactions with the Terminally Blocked Hexapeptide Ac-Leu-Ala-His-Tyr-Asn-Lys-amide Model of Histone H2B (80–85)

Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri--Butyltin(IV) with 2-Thiobarbituric Acid

Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water

Synthesis, Characterization, and Biological Activity of -Methyl-2-(-1,2,3-Benzotriazol-1-y1)-3-Oxobutan-ethioamide Complexes with Some Divalent Metal (II) Ions