In recent years, advanced bioinorganic materials have been widely synthesized and used for various applications. In focus are nanotechnology-based materials with functional biochemical properties that can be used in medical and pharmaceutical fields. Typically, inorganic ions play an important role in binding with biomolecules showing antioxidant, anti-inflammatory, antibiosis, anti-cancer, drug carrying, and molecular imaging properties. Although many advanced products have been successfully manufactured (i.e. metal organic frameworks, photosensitizers), the actual use of these materials still face problems in safety, production, policy, cost, ethics, market, etc. In particular, the mechanisms of in vivo and in vitro biochemical behaviors of these bioinorganic materials need to be studied further for use in medical and pharmaceutical applications.

Material science is the key area to be studied for the advanced bioinorganic materials relating to biochemical synthesis, molecular interactions, instrumental analysis, and industrial production. These processes affect the in vivo and in vitro biochemical behaviors of bioinorganic materials, which are crucial to the development of the advanced medical and pharmaceutical technology. Subsequently, medical and pharmaceutical studies are required to assess the feasibility of these bioinorganic materials in practice. Relative works may contain pharmaceutical formulations, cell experiments, animal tests, clinical trials, and medical analysis. Experimental observation, mathematical modeling, namely in silico research, and ethical investigation are also important to evaluate the in vivo and in vitro works.

The aim of this Special Issue is to collate articles providing valuable inputs in the design and use of advanced bioinorganic materials for biomedicine. Submissions revealing in vivo and in vitro biochemical behaviors are encouraged. Moreover, we hope that this Special Issue increases our understanding of related biochemical technologies. Review articles discussing the state of the art are also welcome.

Potential topics include but are not limited to the following:

• Synthesis of novel materials
• Theoretical studies
• Biochemical analysis techniques
• Medical and clinical cases
• Pharmaceutical applications
• Environmental and energy applications
• Microbiology and microenvironments
• Toxicology, symptoms, and adverse reactions
• Molecular interactions
• Ethical research and social-science studies