Research Article
Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin
Table 1
Motility speed-pCa regression parameter estimates for regulated thin filaments containing HcTn and WT or mutant tropomyosin.
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Speed-pCa data from regulated motility assays (Figure 3) were fit to (4) by nonlinear least squares regression (Methods). Values are regression parameter estimates ±SE. Parameter estimates of pCa50 and that are significantly different from those for α-GS-Tm WT are indicated by *(). |