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Bone Marrow Research
Volume 2012 (2012), Article ID 680841, 7 pages
Review Article

Role of HLA in Hematopoietic Stem Cell Transplantation

1Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
2Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea

Received 27 July 2012; Accepted 3 September 2012

Academic Editor: Andrzej Lange

Copyright © 2012 Meerim Park and Jong Jin Seo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The selection of hematopoietic stem cell transplantation (HSCT) donors includes a rigorous assessment of the availability and human leukocyte antigen (HLA) match status of donors. HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection.