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Journal of Biomedicine and Biotechnology
Volume 1, Issue 2, Pages 85-88
Review article

High-Pressure Biotechnology in Medicine and Pharmaceutical Science

1Centre de Recherches du Service de Santé des Armées, Département de Toxicologie, Unité d'Enzymologie, BP 87, La Tronche cédex 38702, France
2Hautes Pressions Technologies, Chemin des Romains, Bar le Duc 55000, France
3INSERM U128, IFR24, CNRS, 1919, route de Mende, Montpellier Cédex 5 34293, France

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High-pressure (HP) biotechnology is an emerging technique initially applied for food processing and more recently in pharmaceutical and medical sciences. Pressure can stabilize enzymes and modulate both their activity and specificity. HP engineering of proteins may be used for enzyme-catalyzed synthesis of fine chemicals, pharmaceuticals, and production of modified proteins of medical or pharmaceutical interest. HP inactivation of biological agents is expected to be applicable to sterilization of fragile biopharmaceuticals, or medical compounds. The enhanced immunogenicity of some pressure-killed bacteria and viruses could be applied for making new vaccines. Finally, storage at subzero temperatures without freezing is another potential application of HP for cells, animal tissues, blood cells, organs for transplant, and so forth.