BioMed Research International

BioMed Research International / 2002 / Article
Special Issue

DNA Damage, Repair, and Diseases

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Review article | Open Access

Volume 2 |Article ID 798128 |

Alexander J. R. Bishop, Robert H. Schiestl, "Homologous Recombination and Its Role in Carcinogenesis", BioMed Research International, vol. 2, Article ID 798128, 11 pages, 2002.

Homologous Recombination and Its Role in Carcinogenesis

Received09 Jan 2002
Revised29 Apr 2002
Accepted29 Apr 2002


Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into precancerous clones. Over the last decade, many studies have revealed the relevance of genomic mutation in this process, be it by misreplication, environmental damage, or a deficiency in repairing endogenous and exogenous damage. Here, we discuss homologous recombination as another mechanism that can result in a loss of heterozygosity or genetic rearrangements. Some of these genetic alterations may play a primary role in carcinogenesis, but they are more likely to be involved in secondary and subsequent steps of carcinogenesis by which recessive oncogenic mutations are revealed. Patients, whose cells display an increased frequency of recombination, also have an elevated frequency of cancer, further supporting the link between recombination and carcinogenesis.

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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