BioMed Research International

BioMed Research International / 2003 / Article

Review article | Open Access

Volume 2003 |Article ID 313828 |

Carlos E. Semino, "Can We Build Artificial Stem Cell Compartments?", BioMed Research International, vol. 2003, Article ID 313828, 6 pages, 2003.

Can We Build Artificial Stem Cell Compartments?

Received18 Apr 2002
Revised15 May 2002
Accepted21 May 2002


Animals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional environment consisting of other nearby cells extracellular matrix components, endogenous or exogenous soluble factors, and physical, structural, or mechanical properties of the tissues they inhabit. Can we artificially recreate tissue development such that stem cells can both self-renew and be instructed to mature properly? The main factors required to regulate the maintenance and differentiation of some types of stem cells are known. In addition, new bioengineered synthetic materials that mimic extracellular matrix components can be used as initial scaffolding for building stem cell microenvironments.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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