BioMed Research International

BioMed Research International / 2003 / Article

Review article | Open Access

Volume 2003 |Article ID 503547 | https://doi.org/10.1155/S1110724303209165

George F. Muschler, Ronald J. Midura, Chizu Nakamoto, "Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics", BioMed Research International, vol. 2003, Article ID 503547, 24 pages, 2003. https://doi.org/10.1155/S1110724303209165

Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics

Received13 Sep 2002
Revised15 Jan 2003
Accepted23 Jan 2003

Abstract

Stem cell activation and development is central to skeletal development, maintenance, and repair, as it is for all tissues. However, an integrated model of stem cell proliferation, differentiation, and transit between functional compartments has yet to evolve. In this paper, the authors review current concepts in stem cell biology and progenitor cell growth and differentiation kinetics in the context of bone formation. A cell-based modeling strategy is developed and offered as a tool for conceptual and quantitative exploration of the key kinetic variables and possible organizational hierarchies in bone tissue development and remodeling, as well as in tissue engineering strategies for bone repair.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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