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Journal of Biomedicine and Biotechnology
Volume 2003, Issue 3, Pages 170-193
Review article

Practical Modeling Concepts for Connective Tissue Stem Cell and Progenitor Compartment Kinetics

1Department of Orthopeadic Surgery (A-41), The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland 44195, OH, USA
2Department of Biomedical Engineering (ND-20) and The Orthopeadic Research Centre, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland 44195, OH, USA

Received 13 September 2002; Revised 15 January 2003; Accepted 23 January 2003

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Stem cell activation and development is central to skeletal development, maintenance, and repair, as it is for all tissues. However, an integrated model of stem cell proliferation, differentiation, and transit between functional compartments has yet to evolve. In this paper, the authors review current concepts in stem cell biology and progenitor cell growth and differentiation kinetics in the context of bone formation. A cell-based modeling strategy is developed and offered as a tool for conceptual and quantitative exploration of the key kinetic variables and possible organizational hierarchies in bone tissue development and remodeling, as well as in tissue engineering strategies for bone repair.