BioMed Research International

BioMed Research International / 2003 / Article
Special Issue

Proteomics in Health and Disease Part I

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Review article | Open Access

Volume 2003 |Article ID 874759 |

Guru Reddy, Enrique A. Dalmasso, "SELDI ProteinChip® Array Technology: Protein-Based Predictive Medicine and Drug Discovery Applications", BioMed Research International, vol. 2003, Article ID 874759, 5 pages, 2003.

SELDI ProteinChip® Array Technology: Protein-Based Predictive Medicine and Drug Discovery Applications

Received24 Oct 2002
Accepted05 Nov 2002


Predictive medicine, utilizing the ProteinChip® Array technology, will develop through the implementation of novel biomarkers and multimarker patterns for detecting disease, determining patient prognosis, monitoring drug effects such as efficacy or toxicity, and for defining treatment options. These biomarkers may also serve as novel protein drug candidates or protein drug targets. In addition, the technology can be used for discovering small molecule drugs or for defining their mode of action utilizing protein-based assays. In this review, we describe the following applications of the ProteinChip Array technology: (1) discovery and identification of novel inhibitors of HIV-1 replication, (2) serum and tissue proteome analysis for the discovery and development of novel multimarker clinical assays for prostate, breast, ovarian, and other cancers, and (3) biomarker and drug discovery applications for neurological disorders.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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