Data Mining in Genomics and ProteomicsView this Special Issue
Research article | Open Access
Elizabeth H. Corder, John F. Ervin, Evelyn Lockhart, Mari H. Szymanski, Donald E. Schmechel, Christine M. Hulette, "Cardiovascular Damage in Alzheimer Disease: Autopsy Findings From the Bryan ADRC", BioMed Research International, vol. 2005, Article ID 709642, 9 pages, 2005. https://doi.org/10.1155/JBB.2005.189
Cardiovascular Damage in Alzheimer Disease: Autopsy Findings From the Bryan ADRC
Autopsy information on cardiovascular damage was investigated for pathologically confirmed Alzheimer disease (AD) patients () and non-AD control patients (). The 51 relevant items were entered into a grade-of-membership model to describe vascular damage in AD. Five latent groups were identified “I: early-onset AD,” “II: controls, cancer,” “III: controls, extensive atherosclerosis,” “IV: late-onset AD, male,” and “V: late-onset AD, female.” Expectedly, Groups IV and V had elevated APOE frequency. Unexpectedly, there was limited atherosclerosis and frequent myocardial valve and ventricular damage. The findings do not indicate a strong relationship between atherosclerosis and AD, although both are associated with the APOE. Instead, autopsy findings of extensive atherosclerosis were associated with possible, not probable or definite AD, and premature death. They are consistent with the hypothesis that brain hypoperfusion contributes to dementia, possibly to AD pathogenesis, and raise the possibility that the APOE allele contributes directly to heart valve and myocardial damage.
Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.