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Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 24038, 5 pages
Research Article

Heme Deficiency in Alzheimer’s Disease: A Possible Connection to Porphyria

1Research Service (151), VA Medical ’ Regional Office Center, White River Junction, VT 05009, USA
2Department of Medicine (Neurology), Dartmouth Medical School, Hanover, NH 03755, USA
3Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA

Received 1 December 2005; Revised 30 March 2006; Accepted 5 April 2006

Copyright © 2006 Barney E. Dwyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

The following is the list of published articles that have cited the current article.

  • Luisa Benerini Gatta, Massimiliano Vitali, Rosanna Verardi, Paolo Arosio, and Dario Finazzi, “Inhibition of heme synthesis alters Amyloid Precursor Protein processing,” Journal of Neural Transmission, vol. 116, no. 1, pp. 79–88, 2009. View at Publisher · View at Google Scholar
  • Reza Khodarahmi, Hosnieh Soori, and Seyyed Arash Karimi, “Chaperone-like activity of heme group against amyloid-like fibril formation by hen egg ovalbumin: Possible mechanism of action,” International Journal Of Biological Macromolecules, vol. 44, no. 1, pp. 98–106, 2009. View at Publisher · View at Google Scholar
  • Reza Khodarahmi, Fardin Naderi, Ali Mostafaie, and Kamran Mansouri, “Heme, as a chaperone, binds to amyloid fibrils and forms peroxidase in vitro: Possible evidence on critical role of non-specific peroxidase activity in neurodegenerative disease onset/progression using the alpha-crystallin-based experimental system,” Archives Of Biochemistry And Biophysics, vol. 494, no. 2, pp. 205–215, 2010. View at Publisher · View at Google Scholar
  • Dhiman Maitra, Jaeman Byun, Peter R. Andreana, Ibrahim Abdulhamid, Ghassan M. Saed, Michael P. Diamond, Subramaniam Pennathur, and Husam M. Abu-Soud, “Mechanism of hypochlorous acid-mediated heme destruction and free iron release,” Free Radical Biology and Medicine, vol. 51, no. 2, pp. 364–373, 2011. View at Publisher · View at Google Scholar
  • Meng Li, Chuanqi Zhao, Taicheng Duan, Jinsong Ren, and Xiaogang Qu, “New Insights Into Alzheimer's Disease Amyloid Inhibition: Nanosized Metallo-Supramolecular Complexes Suppress Aβ-Induced Biosynthesis of Heme and Iron Uptake in PC12 Cells,” Advanced Healthcare Materials, 2013. View at Publisher · View at Google Scholar