Neurodegenerative Diseases: Mechanisms and TherapiesView this Special Issue
Research Article | Open Access
Elizabeth H. Corder, George D. Mellick, "Parkinson's Disease in Relation to Pesticide Exposure and Nuclear Encoded Mitochondrial Complex I Gene Variants", BioMed Research International, vol. 2006, Article ID 027601, 8 pages, 2006. https://doi.org/10.1155/JBB/2006/27601
Parkinson's Disease in Relation to Pesticide Exposure and Nuclear Encoded Mitochondrial Complex I Gene Variants
Parkinson's disease (PD) is a common age-related neurodegenerative disorder thought to result from the integrated effects of genetic background and exposure to neuronal toxins. Certain individual nuclear-encoded mitochondrial complex I gene polymorphisms were found to be associated with -fold risk variation in an Australian case-control sample. We further characterized this sample of cases and controls to determine the mutual information contained in the SNPs and, additionally, level of pesticide exposure: five distinct risk sets were identified using grade-of-membership analysis. Of these, one was robust to pesticide exposure (I), three were vulnerable (II, III, IV), and another (V) denoted low risk for unexposed persons. Risk for individual subjects varied -fold according to level of membership in the vulnerable groups. We conclude that inherited variation in mitochondrial complex I genes and pesticide exposure together modulate risk for PD.
- G D Mellick, P A Silburn, J A Prince, and A J Brookes, “A novel screen for nuclear mitochondrial gene associations with Parkinson's disease,” Journal of Neural Transmission, vol. 111, no. 2, pp. 191–199, 2004.
- Y Liu and H Yang, “Environmental toxins and alpha-synuclein in Parkinson's disease,” Molecular Neurobiology, vol. 31, no. 1–3, pp. 273–282, 2005.
- S Yu, K Ueda, and P Chan, “Alpha-synuclein and dopamine metabolism,” Molecular Neurobiology, vol. 31, no. 1–3, pp. 243–254, 2005.
- J H Son, H Kawamata, M S Yoo et al., “Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons,” Journal of Neurochemistry, vol. 94, no. 4, pp. 1040–1053, 2005.
- D G Le Couteur, A J McLean, M C Taylor, B L Woodham, and P G Board, “Pesticides and Parkinson's disease,” Biomedecine & Pharmacotherapy, vol. 53, no. 3, pp. 122–130, 1999.
- D G Le Couteur, M Muller, M C Yang, G D Mellick, and A J McLean, “Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease,” Reviews on Environmental Health, vol. 17, no. 1, pp. 51–64, 2002.
- M M Mouradian, “Recent advances in the genetics and pathogenesis of Parkinson disease,” Neurology, vol. 58, no. 2, pp. 179–185, 2002.
- M Meulener, A J Whitworth, C E Armstrong-Gold et al., “Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease,” Current Biology, vol. 15, no. 17, pp. 1572–1577, 2005.
- B Ritz and F Yu, “Parkinson's disease mortality and pesticide exposure in California 1984–1994,” International Journal of Epidemiology, vol. 29, no. 2, pp. 323–329, 2000.
- J A Smeitink, L W van den Heuvel, W J Koopman, L G Nijtmans, C Ugalde, and P H Willems, “Cell biological consequences of mitochondrial NADH: ubiquinone oxidoreductase deficiency,” Current Neurovascular Research, vol. 1, no. 1, pp. 29–40, 2004.
- J A Smeitink, L W van den Heuvel, and S DiMauro, “The genetics and pathology of oxidative phosphorylation,” Nature Reviews. Genetics, vol. 2, no. 5, pp. 342–352, 2001.
- S Sveinbjornsdottir, A A Hicks, T Jonsson et al., “Familial aggregation of Parkinson's disease in Iceland,” The New England Journal of Medicine, vol. 343, no. 24, pp. 1765–1770, 2000.
- A Solano, M Roig, C Vives-Bauza et al., “Bilateral striatal necrosis associated with a novel mutation in the mitochondrial ND6 gene,” Annals of Neurology, vol. 54, no. 4, pp. 527–530, 2003.
- C Vives-Bauza, A L Andreu, G Manfredi et al., “Sequence analysis of the entire mitochondrial genome in Parkinson's disease,” Biochemical and Biophysical Research Communications, vol. 290, no. 5, pp. 1593–1601, 2002.
- N Hattori, H Yoshino, M Tanaka, H Suzuki, and Y Mizuno, “Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease,” Genomics, vol. 49, no. 1, pp. 52–58, 1998.
- A Elbaz, C Levecque, J Clavel et al., “CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease,” Annals of Neurology, vol. 55, no. 3, pp. 430–434, 2004.
- Y Deng, B Newman, M P Dunne, P A Silburn, and G D Mellick, “Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease,” Annals of Neurology, vol. 55, no. 6, p. 897, 2004.
- E H Corder, R Huang, H M Cathcart et al., “Membership in genetic groups predicts Alzheimer disease,” Rejuvenation Research, vol. 9, no. 1, pp. 89–93, 2006.
- E H Corder and L A Hefler, “Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma,” Rejuvenation Research, vol. 9, no. 1, pp. 56–60, 2006.
- C E Gartner, D Battistutta, M P Dunne, P A Silburn, and G D Mellick, “Test-retest repeatability of self-reported environmental exposures in Parkinson's disease cases and healthy controls,” Parkinsonism & Related Disorders, vol. 11, no. 5, pp. 287–295, 2005.
- W M Howell, M Jobs, U Gyllensten, and A J Brookes, “Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms,” Nature Biotechnology, vol. 17, no. 1, pp. 87–88, 1999.
- J A Prince, L Feuk, W M Howell et al., “Robust and accurate single nucleotide polymorphism genotyping by dynamic allele-specific hybridization (DASH): design criteria and assay validation,” Genome Research, vol. 11, no. 1, pp. 152–162, 2001.
- M A Woodbury and J Clive, “Clinical pure types as a fuzzy partition,” Journal of Cybernetics, vol. 4, pp. 111–121, 1974.
- M A Woodbury, J Clive, and A Garson, “Mathematical typology: a grade of membership technique for obtaining disease definition,” Computers and Biomedical Research, vol. 11, no. 3, pp. 277–298, 1978.
- M A Woodbury, K G Manton, and D H Tolley, “A general model for statistical analysis using fuzzy sets: sufficient conditions for identifiability and statistical properties,” Information Sciences, vol. 1, pp. 149–180, 1994.
- L M de Lau, P C Giesbergen, M C de Rijk, A Hofman, P J Koudstaal, and M M Breteler, “Incidence of parkinsonism and Parkinson disease in a general population: the Rotterdam Study,” Neurology, vol. 63, no. 7, pp. 1240–1244, 2004.
- K G Manton, L S Corder, and E Stallard, “Estimates of change in chronic disability and institutional incidence and prevalence rates in the U.S. elderly population from the 1982, 1984, and 1989 National Long Term Care Survey,” Journal of Gerontology, vol. 48, no. 4, pp. S153–S166, 1993.
- A Jablensky and M A Woodbury, “Dementia praecox and manic-depressive insanity in 1908: a Grade of Membership analysis of the Kraepelinian dichotomy,” European Archives of Psychiatry and Clinical Neuroscience, vol. 245, no. 4-5, pp. 202–209, 1995.
- J F Hallmayer, L Kalaydjieva, J Badcock et al., “Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit,” American Journal of Human Genetics, vol. 77, no. 3, pp. 468–476, 2005.
- E H Corder, M A Woodbury, K G Manton, and L L Field, “Grade-of-membership sibpair linkage analysis maps the IDDM11 locus to chromosome 14q24.3-q31: a pattern recognition approach to linkage,” Annals of Human Genetics, vol. 65, pp. 387–394, 2001.
- E H Corder, M A Woodbury, I Volkmann, D K Madsen, N Bogdanovic, and B Winblad, “Density profiles of Alzheimer disease regional brain pathology for the Huddinge Brain Bank: pattern recognition emulates and expands upon Braak staging,” Experimental Gerontology, vol. 35, no. 6-7, pp. 851–864, 2000.
- E H Corder, J F Ervin, E Lockhart, M H Szymanski, D E Schmechel, and C M Hulette, “Cardiovascular damage in Alzheimer disease: autopsy findings from the Bryan ADRC,” Journal of Biomedicine and Biotechnology, vol. 2005, no. 2, pp. 189–197, 2005.
- S Iivonen, E H Corder, M Lehtovirta et al., “Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease,” Neurology, vol. 62, no. 7, pp. 1170–1176, 2004.
- S Helisalmi, M Hiltunen, S Vepsäläinen et al., “Genetic variation in apolipoprotein D and Alzheimer's disease,” Journal of Neurology, vol. 251, no. 8, pp. 951–957, 2004.
Copyright © 2006 Elizabeth H. Corder and George D. Mellick. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.