Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2006, Article ID 97896, 12 pages
http://dx.doi.org/10.1155/JBB/2006/97896
Research Article

Determination of DNA Damage in Floriculturists Exposed to Mixtures of Pesticides

1Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Universidad Autónoma del Estado de México, Mexico
2Facultad de Química, Universidad Autónoma del Estado de México, Mexico
3Laboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala s/n,Santo Tomás, CP, Mexico, DF 11340, Mexico

Received 5 April 2005; Revised 18 October 2005; Accepted 19 October 2005

Copyright © 2006 J. Castillo-Cadena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C D Klaassen, Casarett & Doull's Toxicology: The Basic Science of Poisons, McGraw-Hill, New York, NY, 6th edition, 2001.
  2. R C Sobti, A Krishan, and C D Pfaffenberger, “Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates,” Mutation Research/Genetic Toxicology, vol. 102, no. 1, pp. 89–102, 1982. View at Publisher · View at Google Scholar
  3. C Bolognesi, M Peluso, P Degan, R Rabboni, A Munnia, and A Abbondandolo, “Genotoxic effects of the carbamate insecticide, methyomyl. II. In vivo studies with pure compound and the technical formulation, “Lannate 25”,” Environmental and Molecular Mutagenesis, vol. 24, no. 3, pp. 235–242, 1994. View at Publisher · View at Google Scholar
  4. B Debuyst and N Van Larebeke, “Induction of sister chromatid exchange in human lymphocytes by aldicarb, thiophanox and methomyl,” Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 113, no. 3-4, pp. 242–243, 1983. View at Publisher · View at Google Scholar
  5. S Bonatti, C Bolognesi, P Degan, and A Abbondandolo, “Genotoxic effects of the carbamate insecticide methomyl. I. In vitro studies with pure compound and the technical formulation “Lannate 25”,” Environmental and Molecular Mutagenesis, vol. 23, no. 4, pp. 306–311, 1994. View at Publisher · View at Google Scholar
  6. C Bolognesi, “Genotoxicity of pesticides: a review of human biomonitoring studies,” Mutation Research/Reviews in Mutation Research, vol. 543, no. 3, pp. 251–272, 2003. View at Publisher · View at Google Scholar
  7. M Varona, O Cárdenas, C Crane, S Rocha, G Cuervo, and J Vargas, “Alteraciones citogenéticas en trabajadoras con riesgo ocupacional de exposición a plaguicidas en cultivo de flores en Bogotá [Cytogenetic alterations in field workers routinely exposed to pesticides in Bogota flowers farms],” Biomédica, vol. 23, no. 2, pp. 141–152, 2003. View at Google Scholar
  8. C Bolognesi, E Landini, E Perrone, and P Roggieri, “Cytogenetic biomonitoring of a floriculturist population in Italy: micronucleus analysis by Fluorescence In Situ Hybridization (FISH) with an all-chromosome centromeric probe,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 557, no. 2, pp. 109–117, 2004. View at Publisher · View at Google Scholar
  9. S M Piperakis, E Petrakou, S Tsilimigaki et al., “Biomonitoring with the comet assay of Greek greenhouse workers exposed to pesticides,” Environmental and Molecular Mutagenesis, vol. 41, no. 2, pp. 104–110, 2003. View at Publisher · View at Google Scholar
  10. F Faust, F Kassie, S Knasmüller, R H Boedecker, M Mann, and V Mersch-Sundermann, “The use of the alkaline comet assay with lymphocytes in human biomonitoring studies,” Mutation Research/Reviews in Mutation Research, vol. 566, no. 3, pp. 209–229, 2004. View at Publisher · View at Google Scholar
  11. R R Tice, E Agurell, D Anderson et al., “Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing,” Environmental and Molecular Mutagenesis, vol. 35, no. 3, pp. 206–221, 2000. View at Publisher · View at Google Scholar
  12. L Martínez-Tabche, E Madrigal-Bujaidar, and T Negrete, “Genotoxicity and lipoperoxidation produced by paraquat and 2,4-dichlorophenoxyacetic acid in the gills of rainbow trout (Oncorhynchus mikiss),” Bulletin of Environmental Contamination and Toxicology, vol. 73, no. 1, pp. 146–152, 2004. View at Google Scholar
  13. N P Singh, D B Danner, R R Tice, L Brant, and E L Schneider, “DNA damage and repair with age in individual human lymphocytes,” Mutation Research/DNAging, vol. 237, no. 3-4, pp. 123–130, 1990. View at Publisher · View at Google Scholar
  14. S Bonassi, M Ceppi, V Fontana, and F Merlo, “Multiple regression analysis of cytogenetic human data,” Mutation Research/Environmental Mutagenesis and Related Subjects, vol. 313, no. 1, pp. 69–80, 1994. View at Publisher · View at Google Scholar
  15. E Lacassie, M F Dreyfuss, J M Gaulier, P Marquet, J L Daguet, and G Lachâtre, “Multiresidue determination method for organophosphorus pesticides in serum and whole blood by gas chromatography-mass-selective detection,” Journal of Chromatography B: Biomedical Sciences and Applications, vol. 759, no. 1, pp. 109–116, 2001. View at Publisher · View at Google Scholar
  16. Y A Barnett and C R Barnett, “DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses?” Mechanisms of Ageing and Development, vol. 102, no. 2-3, pp. 165–175, 1998. View at Publisher · View at Google Scholar
  17. C Andreoli, S Rossi, P Leopardi, and R Crebelli, “DNA damage by hydroquinone in human white blood cells: analysis by alkaline single-cell gel electrophoresis,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 438, no. 1, pp. 37–45, 1999. View at Publisher · View at Google Scholar
  18. Environmental Protection Agency (EPA), “Guides to Pollution Prevention; The Pesticide Formulating Industry (EPA/625/7-90-004),” Cincinnati, Ohio: EPA; 1990.
  19. R C Repetto and S S Baliga, Pesticides and the Immune System: The Public Health Risks, World Resources Institute, Washington, DC, 1996.
  20. B Bilgici, A Bedir, N Şentürk, M Alvur, F Aydin, and A Y Turanli, “Genotoxicity assessment using comet assay in Behcet's disease patients,” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 578, no. 1-2, pp. 170–174, 2005. View at Publisher · View at Google Scholar
  21. C Bolognesi, E Landini, E Perrone, and P. Roggieri, “Cytogenetic biomonitoring of a floriculturist population in Italy: micronucleus analysis by Fluorescence In Situ Hybridization (FISH) with an all-chromosome centromeric probe,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 557, no. 2, pp. 109–117, 2004. View at Publisher · View at Google Scholar
  22. L K Chauhan, N Pant, S K Gupta, and S P Srivastava, “Induction of chromosome aberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 465, no. 1-2, pp. 123–129, 2000. View at Publisher · View at Google Scholar
  23. B Elliott, “Review of the genotoxicity of 4-chloro-2-methylphenoxyacetic acid,” Mutagenesis, vol. 20, no. 1, pp. 3–13, 2005. View at Publisher · View at Google Scholar
  24. A Jablonická, H Poláková, J Karelová, and M Vargová, “Analysis of chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of workers with occupational exposure to the mancozeb-containing fungicide Novozir Mn80,” Mutation Research/Genetic Toxicology, vol. 224, no. 2, pp. 143–146, 1989. View at Google Scholar
  25. S Soloneski, M A Reigosa, and M L Larramendy, “Effect of dithiocarbamate pesticide zineb and its commercial formulation, azzurro. II. micronucleus induction in immunophenotyped human lymphocytes,” Environmental and Molecular Mutagenesis, vol. 40, no. 1, pp. 57–62, 2002. View at Publisher · View at Google Scholar
  26. J Mäki-Paakkanen, M Laaksonen, T Munter, L Kronberg, and H Komulainen, “Comparable DNA and chromosome damage in Chinese hamster ovary cells by chlorohydroxyfuranones,” Environmental and Molecular Mutagenesis, vol. 38, no. 4, pp. 297–305, 2001. View at Google Scholar
  27. C Padungtod, T J Hassold, E Millie et al., “Sperm aneuploidy among Chinese pesticide factory workers: scoring by the FISH method,” American Journal of Industrial Medicine, vol. 36, no. 2, pp. 230–238, 1999. View at Publisher · View at Google Scholar
  28. D S Rupa, P P Reddy, and O S Reddi, “Cytogeneticity of quinalphos and methyl parathion in human peripheral lymphocytes,” Human & Experimental Toxicology, vol. 9, no. 6, pp. 385–387, 1990. View at Google Scholar
  29. Ü Ündeger, L Institóris, O Siroki, M Nehéz, and I Dési, “Simultaneous geno-and immunotoxicological investigations for early detection of organophosphate toxicity in rats,” Ecotoxicology and Environmental Safety, vol. 45, no. 1, pp. 43–48, 2000. View at Google Scholar
  30. S M Amer, S M Donya, and F A Aly, “Genotoxicity of benomyl and its residues in somatic and germ cells of mice fed on treated stored wheat grains,” Archives of Toxicology, vol. 77, no. 12, pp. 712–721, 2003. View at Publisher · View at Google Scholar
  31. K S Bentley, D Kirkland, M Murphy, and R Marshall, “Evaluation of thresholds for benomyl-and carbendazim-induced aneuploidy in cultured human lymphocytes using Fluorescence In Situ Hybridization,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 464, no. 1, pp. 41–51, 2000. View at Publisher · View at Google Scholar
  32. P Dolara, M Salvadori, T Capobianco, and F Torricelli, “Sister-chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture,” Mutation Research Letters, vol. 283, no. 2, pp. 113–118, 1992. View at Publisher · View at Google Scholar
  33. O I Kalantzi, R Hewitt, K J Ford et al., “Low dose induction of micronuclei by lindane,” Carcinogenesis, vol. 25, no. 4, pp. 613–622, 2004. View at Publisher · View at Google Scholar
  34. B Saleha Banu, K Danadevi, M F Rahman, Y R Ahuja, and J Kaiser, “Genotoxic effect of monocrotophos to sentinel species using comet assay,” Food and Chemical Toxicology, vol. 39, no. 4, pp. 361–366, 2001. View at Publisher · View at Google Scholar
  35. K Jamil, A P Shaik, M Mahboob, and D Krishna, “Effect of organophosphorus and organochlorine pesticides (monochrotophos, chlorpyriphos, dimethoate, and endosulfan) on human lymphocytes in-vitro,” Drug and Chemical Toxicology, vol. 27, no. 2, pp. 133–144, 2004. View at Publisher · View at Google Scholar
  36. M Mahboob, M F Rahman, K Danadevi, B Saleha Banu, and P Grover, “Detection of DNA damage in mouse peripheral blood leukocytes by the comet assay after oral administration of monocrotophos,” Drug and Chemical Toxicology, vol. 25, no. 1, pp. 65–74, 2002. View at Publisher · View at Google Scholar
  37. D Zeljezic and V Garaj-Vrhovac, “Chromosomal aberration and single cell gel electrophoresis (Comet) assay in the longitudinal risk assessment of occupational exposure to pesticides,” Mutagenesis, vol. 16, no. 4, pp. 359–363, 2001. View at Publisher · View at Google Scholar
  38. P Grover, K Danadevi, M Mahboob, R Rozati, B Saleha Banu, and M F Rahman, “Evaluation of genetic damage in workers employed in pesticide production utilizing the Comet assay,” Mutagenesis, vol. 18, no. 2, pp. 201–205, 2003. View at Publisher · View at Google Scholar
  39. A Arévila, J Ramos, and B Jiménez, “Evaluación de la contaminación dispersa por agroquímicos en México,” Ingeniería Ambiental, vol. 1, pp. 26–30, 1997. View at Google Scholar
  40. J Finkelman, Epidemiología Ambiental: Un proyecto para América Latina y el Caribe, Organización Panamericana de la Salud y Organización Mundial de la Salud, México, 1era edition, 1994.
  41. E Carbonell, A Valbuena, N Xamena, A Creus, and R Marcos, “Temporary variations in chromosomal aberrations in a group of agricultural workers exposed to pesticides,” Mutation Research/Genetic Toxicology, vol. 344, no. 3-4, pp. 127–134, 1995. View at Publisher · View at Google Scholar