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Journal of Biomedicine and Biotechnology
Volume 2007, Article ID 59430, 6 pages
Review Article

CD40-CD40L Interaction in Immunity Against Protozoan Infections

Laboratoire de Bactériologie Moléculaire, Département de Microbiologie, Faculté de Médecine, Université Libre de Bruxelles (U.L.B), 808 Route de Lennik, Bruxelles 1070, Belgium

Received 1 December 2006; Accepted 2 February 2007

Academic Editor: Ali Ouaissi

Copyright © 2007 Mustapha Chamekh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Activation of the immune system against protozoan infections relies particularly on two specific signals provided by cognate interaction of T cells with antigen presenting cells (APCs). The first signal is attributed to binding of the T-cell receptor (TCR) to peptide/MHC complexes on the surface of APCs, whereas the second signal is triggered through binding of several costimulatory molecules on the surface of APCs with their corresponding receptors on T cells. Among these costimulatory signallings, CD40/CD40L interactions have been particularly investigated in protozoan infection models with regard to their potential to amplify cell-mediated immunity against intracellular parasites. This article reviews current studies of the potential role of CD40/CD40L interaction in the modulation of immune responses against some protozoan parasites and highlights recent developments regarding manipulation of this interaction for promoting control of parasite infections.