Stem Cell Fate Analysis Revisited: Interpretation of Individual Clone Dynamics in the Light of a New Paradigm of Stem Cell Organization

Roeder, Ingo; Braesel, Katrin; Lorenz, Ronny; Loeffler, Markus

doi:https://doi.org/10.1155/2007/84656

BioMed Research International

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Research Article | Open Access

Volume 2007 | Article ID 084656 | https://doi.org/10.1155/2007/84656

Stem Cell Fate Analysis Revisited: Interpretation of Individual Clone Dynamics in the Light of a New Paradigm of Stem Cell Organization

Ingo Roeder,¹Katrin Braesel,¹Ronny Lorenz,¹and Markus Loeffler¹

Academic Editor: James L. Sherley

Received01 Nov 2006

Revised02 Jan 2007

Accepted21 Jan 2007

Published11 Mar 2007

Abstract

Many experimental findings on heterogeneity, flexibility, and plasticity of tissue stem cells are currently challenging stem cell concepts that assume a cell intrinsically predefined, unidirectional differentiation program. In contrast to these classical concepts, nonhierarchical self-organizing systems provide an elegant and comprehensive alternative to explain the experimental data. Here we present the application of such a self-organizing concept to quantitatively describe the hematopoietic stem cell system. Focusing on the analysis of individual-stem-cell fates and clonal dynamics, we particularly discuss implications of the theoretical results on the interpretation of experimental findings. We demonstrate that it is possible to understand hematopoietic stem cell organization without assumptions on unidirectional developmental hierarchies, preprogrammed asymmetric division events or other assumptions implying the existence of a predetermined stem cell entity. The proposed perspective, therefore, changes the general paradigm of thinking about stem cells.

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Copyright © 2007 Ingo Roeder et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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