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Journal of Biomedicine and Biotechnology
Volume 2007, Article ID 90651, 7 pages
http://dx.doi.org/10.1155/2007/90651
Research Article

Design of Biotin-Functionalized Luminescent Quantum Dots

1Division of Optical Sciences, U.S. Naval Research Laboratory, Washington, DC 20375, USA
2Center for Bio/Molecular Science and Engineering, U.S. Naval Research Laboratory, Washington, DC 20375, USA
3Promega Biosciences, Inc., 277 Granada Dr., San Luis Obispo, CA 93401, USA

Received 25 June 2007; Accepted 21 December 2007

Academic Editor: Marek Osinski

Copyright © 2007 Kimihiro Susumu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Bruchez Jr., M. Moronne, P. Gin, S. Weiss, and A. P. Alivisatos, “Semiconductor nanocrystals as fluorescent biological labels,” Science, vol. 281, no. 5385, pp. 2013–2016, 1998. View at Publisher · View at Google Scholar
  2. X. Gao, Y. Cui, R. M. Levenson, L. W. K. Chung, and S. Nie, “In vivo cancer targeting and imaging with semiconductor quantum dots,” Nature Biotechnology, vol. 22, no. 8, pp. 969–976, 2004. View at Publisher · View at Google Scholar
  3. B. Dubertret, P. Skourides, D. J. Norris, V. Noireaux, A. H. Brivanlou, and A. Libchaber, “In vivo imaging of quantum dots encapsulated in phospholipid micelles,” Science, vol. 298, no. 5599, pp. 1759–1762, 2002. View at Publisher · View at Google Scholar
  4. W. C. W. Chan and S. Nie, “Quantum dot bioconjugates for ultrasensitive nonisotopic detection,” Science, vol. 281, no. 5385, pp. 2016–2018, 1998. View at Publisher · View at Google Scholar
  5. H. Mattoussi, J. M. Mauro, E. R. Goldman et al., “Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein,” Journal of the American Chemical Society, vol. 122, no. 49, pp. 12142–12150, 2000. View at Publisher · View at Google Scholar
  6. Y. A. Wang, J. J. Li, H. Chen, and X. Peng, “Stabilization of inorganic nanocrystals by organic dendrons,” Journal of the American Chemical Society, vol. 124, no. 10, pp. 2293–2298, 2002. View at Publisher · View at Google Scholar
  7. I. L. Medintz, A. R. Clapp, H. Mattoussi, E. R. Goldman, B. R. Fisher, and J. M. Mauro, “Self-assembled nanoscale biosensors based on quantum dot FRET donors,” Nature Materials, vol. 2, no. 9, pp. 630–638, 2003. View at Publisher · View at Google Scholar
  8. A. R. Clapp, I. L. Medintz, J. M. Mauro, B. R. Fisher, M. G. Bawendi, and H. Mattoussi, “Fluorescence resonance energy transfer between quantum dot donors and dye-labeled protein acceptors,” Journal of the American Chemical Society, vol. 126, no. 1, pp. 301–310, 2004. View at Publisher · View at Google Scholar
  9. A. R. Clapp, I. L. Medintz, and H. Mattoussi, “Förster resonance energy transfer investigations using quantum-dot fluorophores,” ChemPhysChem, vol. 7, no. 1, pp. 47–57, 2006. View at Publisher · View at Google Scholar
  10. F. Patolsky, R. Gill, Y. Weizmann, T. Mokari, U. Banin, and I. Wiliner, “Lighting-up the dynamics of telomerization and DNA replication by CdSe-ZnS quantum dots,” Journal of the American Chemical Society, vol. 125, no. 46, pp. 13918–13919, 2003. View at Publisher · View at Google Scholar
  11. J. B. Delehanty, I. L. Medintz, T. Pons, F. M. Brunel, P. E. Dawson, and H. Mattoussi, “Self-assembled quantum dot-peptide bioconjugates for selective intracellular delivery,” Bioconjugate Chemistry, vol. 17, no. 4, pp. 920–927, 2006. View at Publisher · View at Google Scholar
  12. H. T. Uyeda, I. L. Medintz, J. K. Jaiswal, S. M. Simon, and H. Mattoussi, “Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores,” Journal of the American Chemical Society, vol. 127, no. 11, pp. 3870–3878, 2005. View at Publisher · View at Google Scholar
  13. A. W. Schwabacher, J. W. Lane, M. W. Schiesher, K. M. Leigh, and C. W. Johnson, “Desymmetrization reactions: efficient preparation of unsymmetrically substituted linker molecules,” The Journal of Organic Chemistry, vol. 63, no. 5, pp. 1727–1729, 1998. View at Publisher · View at Google Scholar
  14. S. H. Um, G. S. Lee, Y.-J. Lee, K.-K. Koo, C. Lee, and K. B. Yoon, “Self-assembly of avidin and D-biotin-tethering zeolite microcrystals into fibrous aggregates,” Langmuir, vol. 18, no. 11, pp. 4455–4459, 2002. View at Publisher · View at Google Scholar
  15. N. Charvet, P. Reiss, A. Roget et al., “Biotinylated CdSe/ZnSe nanocrystals for specific fluorescent labeling,” Journal of Materials Chemistry, vol. 14, no. 17, pp. 2638–2642, 2004. View at Publisher · View at Google Scholar
  16. D. Tong, J. Yao, H. Li, and S. Han, “Synthesis and characterization of thermo- and pH-sensitive block copolymers bearing a biotin group at the poly(ethylene oxide) chain end,” Journal of Applied Polymer Science, vol. 102, no. 4, pp. 3552–3558, 2006. View at Publisher · View at Google Scholar
  17. C. B. Murray, D. J. Norris, and M. G. Bawendi, “Synthesis and characterization of nearly monodisperse CdE (E = S, Se, Te) semiconductor nanocrystallites,” Journal of the American Chemical Society, vol. 115, no. 19, pp. 8706–8715, 1993. View at Publisher · View at Google Scholar
  18. M. A. Hines and P. Guyot-Sionnest, “Synthesis and characterization of strongly luminescing ZnS-capped CdSe nanocrystals,” Journal of Physical Chemistry, vol. 100, no. 2, pp. 468–471, 1996. View at Publisher · View at Google Scholar
  19. B. O. Dabbousi, J. Rodriguez-Viejo, F. V. Mikulec et al., “(CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites,” Journal of Physical Chemistry B, vol. 101, no. 46, pp. 9463–9475, 1997. View at Publisher · View at Google Scholar
  20. Z. A. Peng and X. Peng, “Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor,” Journal of the American Chemical Society, vol. 123, no. 1, pp. 183–184, 2001. View at Publisher · View at Google Scholar
  21. A. R. Clapp, E. R. Goldman, and H. Mattoussi, “Capping of CdSe-ZnS quantum dots with DHLA and subsequent conjugation with proteins,” Nature Protocols, vol. 1, no. 3, pp. 1258–1266, 2006. View at Publisher · View at Google Scholar
  22. I. L. Medintz, L. Berti, T. Pons et al., “A reactive peptidic linker for self-assembling hybrid quantum dot-DNA bioconjugates,” Nano Letters, vol. 7, no. 6, pp. 1741–1748, 2007. View at Publisher · View at Google Scholar
  23. F. Pinaud, D. King, H.-P. Moore, and S. Weiss, “Bioactivation and cell targeting of semiconductor CdSe/ZnS nanocrystals with phytochelatin-related peptides,” Journal of the American Chemical Society, vol. 126, no. 19, pp. 6115–6123, 2004. View at Publisher · View at Google Scholar
  24. G. T. Hermanson, in Bioconjugate Techniques, Academic Press, San Diego, Calif, USA, 1996.