Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2007, Article ID 97939, 4 pages
http://dx.doi.org/10.1155/2007/97939
Research Article

EGFR Activation and Ultraviolet Light‐Induced Skin Carcinogenesis

1Cancer Center, Creighton University Medical Center, Omaha 68178, NE, USA
2Department of Biomedical Sciences, School of Medicine, Creighton University, 2500 California Plaza, Omaha 68178, NE, USA

Received 15 December 2006; Accepted 14 February 2007

Academic Editor: Honnavara N. Ananthaswamy

Copyright © 2007 Taghrid B. El-Abaseri and Laura A. Hansen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. Yarden and M. X. Sliwkowski, “Untangling the ErbB signalling network,” Nature Reviews Molecular Cell Biology, vol. 2, no. 2, pp. 127–137, 2001. View at Publisher · View at Google Scholar · View at PubMed
  2. D. W. Threadgill, A. A. Dlugosz, and L. A. Hansen et al., “Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype,” Science, vol. 269, no. 5221, pp. 230–234, 1995. View at Publisher · View at Google Scholar
  3. L. A. Hansen, U. Lichti, and T. Tennenbaum et al., “Altered hair follicle morphogenesis in epidermal growth factor receptor deficient mice,” in Hair Research for the Next Millenium, D. J. J. van Neste and V. A. Randall, Eds., pp. 425–431, Elsevier Science B. V., Amsterdam, The Netherlands, 1996.
  4. L. A. Hansen, N. Alexander, and M. E. Hogan et al., “Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development,” American Journal of Pathology, vol. 150, no. 6, pp. 1959–1975, 1997.
  5. S. K. Repertinger, E. Campagnaro, J. Fuhrman, T. B. El-Abaseri, S. H. Yuspa, and L. A. Hansen, “EGFR enhances early healing after cutaneous incisional wounding,” Journal of Investigative Dermatology, vol. 123, no. 5, pp. 982–989, 2004. View at Publisher · View at Google Scholar · View at PubMed
  6. W. J. Gullick, “Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers,” British Medical Bulletin, vol. 47, no. 1, pp. 87–98, 1991.
  7. M. Scaltriti and J. Baselga, “The epidermal growth factor receptor pathway: a model for targeted therapy,” Clinical Cancer Research, vol. 12, no. 18, pp. 5268–5272, 2006. View at Publisher · View at Google Scholar · View at PubMed
  8. R. Vassar and E. Fuchs, “Transgenic mice provide new insights into the role of TGF-α during epidermal development and differentiation,” Genes and Development, vol. 5, no. 5, pp. 714–727, 1991.
  9. A. M. Dominey, X. J. Wang, and L. E. King et al., “Targeted overexpression of transforming growth factor-α in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squamous papillomas,” Cell Growth and Differentiation, vol. 4, no. 12, pp. 1071–1082, 1993.
  10. M.-A. Shibata, J. M. Ward, J. E. Green, and G. Merlino, “Enhanced sensitivity to tumor growth and development in multistage skin carcinogenesis by transforming growth factor-α-induced epidermal growth factor receptor activation but not p53 inactivation,” Molecular Carcinogenesis, vol. 18, no. 3, pp. 160–170, 1997. View at Publisher · View at Google Scholar
  11. A. A. Dlugosz, L. A. Hansen, and C. Cheng et al., “Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-rasHa oncogene but does not block in vitro keratinocyte responses to oncogenic ras,” Cancer Research, vol. 57, no. 15, pp. 3180–3188, 1997.
  12. L. A. Hansen, R. L. Woodson II, S. Holbus, K. Strain, Y.-C. Lo, and S. H. Yuspa, “The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors,” Cancer Research, vol. 60, no. 13, pp. 3328–3332, 2000.
  13. M. Sibilia, A. Fleischmann, and A. Behrens et al., “The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development,” Cell, vol. 102, no. 2, pp. 211–220, 2000. View at Publisher · View at Google Scholar
  14. R. Zenz, H. Scheuch, and P. Martin et al., “c-Jun regulates eyelid closure and skin tumor development through EGFR signaling,” Developmental Cell, vol. 4, no. 6, pp. 879–889, 2003. View at Publisher · View at Google Scholar
  15. D. Busse, R. S. Doughty, and T. T. Ramsey et al., “Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27KIP1 independent of MAPK activity,” Journal of Biological Chemistry, vol. 275, no. 10, pp. 6987–6995, 2000. View at Publisher · View at Google Scholar
  16. J. Baselga, “Targeting tyrosine kinases in cancer: the second wave,” Science, vol. 312, no. 5777, pp. 1175–1178, 2006. View at Publisher · View at Google Scholar · View at PubMed
  17. R.-P. Huang, J.-X. Wu, Y. Fan, and E. D. Adamson, “UV activates growth factor receptors via reactive oxygen intermediates,” Journal of Cell Biology, vol. 133, no. 1, pp. 211–220, 1996. View at Publisher · View at Google Scholar
  18. Y. Xu, Y. Shao, J. J. Voorhees, and G. J. Fisher, “Oxidative inhibition of receptor-type protein-tyrosine phosphatase κ by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes,” Journal of Biological Chemistry, vol. 281, no. 37, pp. 27389–27397, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. C. Rosette and M. Karin, “Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors,” Science, vol. 274, no. 5290, pp. 1194–1197, 1996. View at Publisher · View at Google Scholar
  20. K. D. Ley and K. A. O. Ellem, “UVC modulation of epidermal growth factor receptor number in HeLa S3 cells,” Carcinogenesis, vol. 13, no. 2, pp. 183–187, 1992. View at Publisher · View at Google Scholar
  21. P. J. Coffer, B. M. Burgering, M. P. Peppelenbosch, J. L. Bos, and W. Kruijer, “UV activation of receptor tyrosine kinase activity,” Oncogene, vol. 11, no. 3, pp. 561–569, 1995.
  22. T. B. El-Abaseri, J. Fuhrman, C. Trempus, I. Shendrik, R. W. Tennant, and L. A. Hansen, “Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor,” Cancer Research, vol. 65, no. 9, pp. 3958–3965, 2005. View at Publisher · View at Google Scholar · View at PubMed
  23. T. B. El-Abaseri, S. Putta, and L. A. Hansen, “Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor,” Carcinogenesis, vol. 27, no. 2, pp. 225–231, 2006. View at Publisher · View at Google Scholar · View at PubMed
  24. J. G. Madson, D. T. Lynch, K. L. Tinkum, S. K. Putta, and L. A. Hansen, “Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation,” American Journal of Pathology, vol. 169, no. 2, pp. 1402–1414, 2006. View at Publisher · View at Google Scholar
  25. Y. S. Wan, Z. Q. Wang, Y. Shao, J. J. Voorhees, and G. J. Fisher, “Ultraviolet irradiation activates PI 3-kinase/AKT survival pathway via EGF receptors in human skin in vivo,” International Journal of Oncology, vol. 18, no. 3, pp. 461–466, 2001.
  26. H. Q. Wang, T. Quan, T. He, T. F. Franke, J. J. Voorhees, and G. J. Fisher, “Epidermal growth factor receptor-dependent, NF-κB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes,” Journal of Biological Chemistry, vol. 278, no. 46, pp. 45737–45745, 2003. View at Publisher · View at Google Scholar · View at PubMed
  27. D. Peus, R. A. Vasa, A. Meves, A. Beyerle, and M. R. Pittelkow, “UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survival,” Photochemistry and Photobiology, vol. 72, no. 1, pp. 135–140, 2000. View at Publisher · View at Google Scholar
  28. R. B. Roberts, C. L. Arteaga, and D. W. Threadgill, “Modeling the cancer patient with genetically engineered mice: prediction of toxicity from molecule-targeted therapies,” Cancer Cell, vol. 5, no. 2, pp. 115–120, 2004. View at Publisher · View at Google Scholar