Jaceosidin Induces Apoptosis in Human Ovary Cancer Cells through Mitochondrial Pathway
Figure 2
Jaceosidin promotes apoptosis of CAOV-3 cells in a
caspase-3-dependent manner. CAOV-3 cells were seeded in 12-well-plate
overnight, and then were treated with different concentrations of jaceosidin or
10 M quercetin in the presence or absence of 100 M Z-DEVD-FMK for 24 hours.
Annexin-V/PI stain was used to measure apoptosis rate. Apoptosis rate
is measured by flow cytometry. (a) The results are representative of three separate experiments. (b) Data are expressed as a
histogram of mean ± s.d. of three independent experiments. (c) Effect of
Z-DEVD-FMK on the proapoptotic activity of jaceosidin. Each datum indicated
mean ± s.d. of three independent experiments. , (Dunnett’s test).
