Research Article
Protein Alterations in Infiltrating Ductal Carcinomas of the Breast as Detected by Nonequilibrium pH Gradient Electrophoresis and Mass Spectrometry
Figure 1
2-DE pattern of proteins from tumor and
nontumor samples resolved by NEPHGE 2-DE and listed in Table 1. Proteins
dysregulated in tumor tissues (T) as compared to nontumor tissues (N) are
highlighted with arrows. The numbers indicated correspond to those given in
Table 1. (1)–(7): proteins downregulated
in tumor tissues; (8)–(20): proteins
upregulated in tumor tissues. (1) complement component C3c; (2)–(6) IGHG1 protein
isoforms; (7) carbonic anhydrase 1; (8) enolase 1; (9) phosphoglycerate kinase
1 (PGK1); (10), (11) hemoglobin; (12) MnSOD; (13) α-B crystallin; (14) Raf kinase inhibitor
protein; (15), (16) peptidylprolylisomerase A (PPIA); (17) cofilin 1; (18), (19)
HSP27; (20) hnRNP A2/B1.