Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional in Vitro and in Vivo
Figure 6
Enhancedcytotoxicities of ifosfamide and cyclophosphamide in T-47D/pPCCMm1 cellsexpressing CYP2B1. Cells were cultivated at increasing amounts of ifosfamidefor five days as described in materials and methods. Cell viabilities weredetermined using an XTT assay and survival rates of CYP2B1 expressing cells inrelation to noninfected control cells were calculated. (a) Incubation of cellswith ifosfamide. (b) Incubation of cells with cyclophosphamide.
