BioMed Research International

Research Article

Characterization of a Novel Polymorphism in PPARG Regulatory Region Associated with Type 2 Diabetes and Diabetic Retinopathy in Italy

Table 2

Genotypes and allele frequencies in diabetic, obese, and control groups (statistical significant values are in bold).
(a)
Control group Diabetic group Obese group
n254211205
Pro12Ala
Pro/Pro 222 (87,5%)179 (84,6%)176 (86%)
Pro/Ala 32 (12,5%)32 (15,4%)28 (13,6%)
Ala/Ala 0 (0%)0 (0%)1 (0,4%)
C1431T
C/C 199 (78,3%)171 (81%)176 (85,9%)
C/T 44 (17,4%)38 (18%)27 (13,2%)
T/T 11 (4,3%)2 (1%)2 (0,9%)
A-2819G
A/A 208 (81,7%)141 (66,7%)165 (80,6%)
A/G 39 (15,4%)64 (30,6%)36 (17,6%)
G/G 7 (2,9%)6 (2,7%)4 (1,8%)
(b)
SNPRisk alleleFrequency of risk alleleRisk allele odds ratio (95% C.I.)P value; statistical power (%)
Pro12Ala Ala Control group Diabetic group Obese group Control/Diabetic Control/Obese Control/Diabetic Control/Obese
0.060.080.081.2 ( )1.1 ( )0.4; 23%0.5; 12.2%
C1431TT
0.130.100.070.74 ( )1.83 ( )0.1; 17.6%
A-2819GG
0.100.180.102.25 ( )1.03 ( ) 0.9; 9%