Effects of FR-91 on Immune Cells from Healthy Individuals and from Patients with Non-Hodgkin Lymphoma

Table 4

Effect of FR-91 on production of cytokines by peripheral blood mononuclear cells from NHL patients.

	IL-1𝛽 control	IL-1𝛽/FR-91 10 micro	IL-1𝛽/FR-91 25 micro
X	2.52±0.2	2.24±0.45	2.21±0.43
	IL-2 control	IL-2/FR-91 10 micro	IL-2/FR-91 25 micro
X	4.67±0.95	7.19±2.58^∗	13.36±5.98^∗
	IL-6 control	IL-6/FR-91 10 micro	IL-6/FR-91 25 micro
X	4.2±0.96	6.89±2.26^∗	14.13±8.04^∗
	IL-8 control	IL-8/FR-91 10 micro	IL-8/FR-91 25 micro
X	2.16±0.34	2.42±0.24	2.21±0.41
	IL-10 control	IL-10/FR-91 10 micro	IL-10/FR-91 25 micro
X	2.18±0.46	2.14±0.48	2.14±0.46
	IL-12 control	IL-12/FR-91 10 micro	IL-12/FR-91 25 micro
X	4.68±0.82	7.61±2.5^∗	16±7.36^∗
	IFN-𝛾 control	IFN-𝛾/FR-91 10 micro	IFN-𝛾/FR-91 25 micro
X	3.86±0.9	5.26±2.02^∗∗	11.84±6.12^∗
	TNF-𝛼 control	TNF-𝛼/FR-91 10 micro	TNF-𝛼/FR-91 25 micro
X	4.86±1.69	15.4±8.4^∗	23.38±7.83^∗

X: mean ± SD; 𝑛=10; ^∗𝑃<.005; ^∗∗𝑃<.05.