Caenorhabditis elegans F09E10.3 Encodes a Putative 3-Oxoacyl-Thioester Reductase of Mitochondrial Type 2 Fatty Acid Synthase FASII that Is Functional in Yeast

Figure 1

Similarity of the C. elegans D1054.8 and F09E10.3 gene products to their bacterial or yeast homologues, FabG and YKL055c (Oar1p), respectively. Comparison of the deduced amino acid sequences was undertaken using Multalin and Genedoc. Dashes indicate the arrangement of the sequences for best fit. Black shadings refer to strictly conserved amino acid residues among all four sequences whereas the darker and lighter grey shadings denote regions with more relaxed residue similarities not necessarily shared by the full set of sequences. MitoProt predictions of cleaved sequences are indicated (D1054.8, *; F09E1.03, +). The catalytic triad of FabG consisting of the amino acid residues serine 148 (S), tyrosine 151 (Y), and lysine 155 (K) are shown in bold below the sequences. Accession numbers used were FabG; AP_001719; D1054.8, CAA98438; F09E10.3, AAB52488; YKL055c, P35731.