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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 275287, 7 pages
Review Article

Rational Design of Improved Pharmabiotics

1Alimentary Pharmabiotic Centre, University College Cork, Ireland
2Department of Biological Sciences, Cork Institute of Technology, Rossa Avenue, Bishopstown, Cork, Ireland

Received 3 April 2009; Revised 18 June 2009; Accepted 22 June 2009

Academic Editor: Don Mark Estes

Copyright © 2009 Roy D. Sleator and Colin Hill. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Herein we review the most recent advances in probiotic research and applications with particular emphasis on the novel concept of patho-biotechnology: the application of pathogen-derived (ex vivo and in vivo) stress survival strategies for the design of more technologically robust and effective probiotic cultures with improved biotechnological and clinical applications.