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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 325210, 5 pages
http://dx.doi.org/10.1155/2009/325210
Research Article

Duchenne and Becker Muscular Dystrophy: Contribution of a Molecular and Immunohistochemical Analysis in Diagnosis in Morocco

1Genetic and Molecular Pathology Laboratory, Medical School, Hassan II University, 19, rue Tarik-Ibn-Ziad, BP 9154, 10000 Casablanca, Morocco
2UFR of Biology and Healthy, Laboratory of Biochemistry and Molecular Biology, Faculty of Sciences, Hassan II University, Ain Chock, PB 5366, Maarif , 20100 Casablanca, Morocco
3Neurology Department, Ibn Rochd Hospital, District Hospitals, Casablanca, Morocco
4Anathomopathology Department, Ibn Rochd Hospital, District Hospitals, Casablanca, Morocco

Received 10 July 2008; Revised 29 December 2008; Accepted 24 February 2009

Academic Editor: Kanury Rao

Copyright © 2009 Hanane Bellayou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. E. H. Emery, “Population frequencies of inherited neuromuscular diseases—a world survey,” Neuromuscular Disorders, vol. 1, no. 1, pp. 19–29, 1991. View at Publisher · View at Google Scholar
  2. M. Koening, E. P. Hoffman, C. J. Bertelson, A. P. Monaco, C. Feener, and L. M. Kunkel, “Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals,” Cell, vol. 50, no. 3, pp. 509–517, 1987. View at Publisher · View at Google Scholar
  3. S. M. Forrest, G. S. Cross, T. Flint, A. Speer, K. J. H. Robson, and K. E. Davies, “Further studies of gene deletions that cause Duchenne and Becker muscular dystrophies,” Genomics, vol. 2, no. 2, pp. 109–114, 1988. View at Publisher · View at Google Scholar
  4. J. T. Den Dunnen, P. M. Grootscholten, E. Bakker et al., “Topography of the Duchenne muscular dystrophy (DMD) gene: FIGE and cDNA analysis of 194 cases reveals 115 deletions and 13 duplications,” The American Journal of Human Genetics, vol. 45, no. 6, pp. 835–847, 1989. View at Google Scholar
  5. X. Hu, A. H. Burghes, P. N. Ray, M. W. Thompson, E. G. Murphy, and R. G. Worton, “Partial gene duplication in Duchenne and Becker muscular dystrophies,” Journal of Medical Genetics, vol. 25, no. 6, pp. 369–376, 1988. View at Publisher · View at Google Scholar
  6. A. P. Monaco, C. J. Bertelson, S. Liechti-Gallati, H. Moser, and L. M. Kunkel, “An explanation for the phenotypic differences between patients bearing partial deletions of the DMD locus,” Genomics, vol. 2, no. 1, pp. 90–95, 1988. View at Publisher · View at Google Scholar
  7. M. Koening, A. H. Beggs, M. Moyer et al., “The molecular basis for Duchenne versus becker muscular dystrophy: correlation of severity with type of deletion,” The American Journal of Human Genetics, vol. 45, no. 4, pp. 498–506, 1989. View at Google Scholar
  8. K. M. Bushby, “The limb-girdle muscular dystrophies: diagnostic guidelines,” European Journal of Paediatric Neurology, vol. 3, no. 2, pp. 53–58, 1999. View at Publisher · View at Google Scholar
  9. K. Ben Othmane, M. C. Speer, J. Stauffer et al., “Evidence for linkage disequilibrium in chromosome 13-linked Duchenne-like muscular dystrophy (LGMD2C),” The American Journal of Human Genetics, vol. 57, no. 3, pp. 732–734, 1995. View at Google Scholar
  10. M. Kefi, R. Amouri, A. Driss et al., “Phenotype and sarcoglycan expression in Tunisian LGMD 2C patients sharing the same del521-T mutation,” Neuromuscular Disorders, vol. 13, no. 10, pp. 779–787, 2003. View at Publisher · View at Google Scholar
  11. M. Yoshida and E. Ozawa, “Glycoprotein complex anchoring dystrophin to sarcolemma,” Journal of Biochemistry, vol. 108, no. 5, pp. 748–752, 1990. View at Google Scholar
  12. E. P. Hoffman, K. H. Fischbeck, R. H. Brown et al., “Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne's or Becker's muscular dystrophy,” The New England Journal of Medicine, vol. 318, no. 21, pp. 1363–1368, 1988. View at Google Scholar
  13. E. P. Hoffman, R. H. Brown Jr., and L. M. Kunkel, “Dystrophin: the protein product of the Duchenne muscular dystrophy locus,” Cell, vol. 51, no. 6, pp. 919–928, 1987. View at Publisher · View at Google Scholar
  14. A. Bonnermann and L. V. Anderson, “Diagnostic protein expression in human muscle biopsies,” Brain Pathology, vol. 10, no. 2, pp. 193–214, 2000. View at Google Scholar
  15. J. S. Chamberlain, R. A. Gibbs, J. E. Ranier, P. N. Nguyen, and C. T. Caskey, “Deletion screening of the Duchenne muscular dystrophy locus viamultiplex DNA amplification,” Nucleic Acids Research, vol. 16, no. 23, pp. 11141–11156, 1988. View at Publisher · View at Google Scholar
  16. A. H. Beggs, M. Koenig, F. M. Boyce, and L. M. Kunkel, “Detection of 98% of DMD/BMD gene deletions by polymerase chain reaction,” Human Genetics, vol. 86, no. 1, pp. 45–48, 1990. View at Publisher · View at Google Scholar
  17. C. A. Sewry, “Immunocytochemical analysis of human muscular dystrophy,” Microscopy Research and Technique, vol. 48, no. 3-4, pp. 142–154, 2000. View at Publisher · View at Google Scholar
  18. L. V. B. Anderson and K. Davison, “Multiplex Western blotting system for the analysis of muscular dystrophy proteins,” The American Journal of Pathology, vol. 154, no. 4, pp. 1017–1022, 1999. View at Google Scholar
  19. A. V. Winnard, C. J. Klein, D. D. Coovert et al., “Characterization of translational frame exception patients in Duchenne/Becker muscular dystrophy,” Human Molecular Genetics, vol. 2, no. 6, pp. 737–744, 1993. View at Publisher · View at Google Scholar