BioMed Research International / 2009 / Article / Fig 1

Research Article

Herpesvirus-Mediated Delivery of a Genetically Encoded Fluorescent Sensor to Canine Cardiomyocytes

Figure 1

This panel shows a part of recombinant herpesvirus genome. To adapt for applicability as virus vector we deleted the two ribonucleotide reductase (rr) and the early protein (ep0) genes from the virus genome by homologue recombination. The rr1 and rr2 genes are in charge for production of raw material of viral DNA. The recombinant virus is not able to productively infect postmitotic cells without rr genes, while ep0 gene is responsible for virus reactivation from latency. Troponeon calcium sensor gene was inserted into the antisense promoter region in two copies.
361795.fig.001

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.