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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 430426, 6 pages
Research Article

Salivary Glucose Concentration and Excretion in Normal and Diabetic Subjects

1Laboratory of Experimental Hormonology, Free University of Brussels, B-1070 Brussels, Belgium
2Endocrinology Department, Istanbul University Medical School, 34390 Istanbul, Turkey

Received 5 February 2009; Accepted 17 March 2009

Academic Editor: Francesca Cutruzzolà

Copyright © 2009 Cedric Jurysta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present report aims mainly at a reevaluation of salivary glucose concentration and excretion in unstimulated and mechanically stimulated saliva in both normal and diabetic subjects. In normal subjects, a decrease in saliva glucose concentration, an increase in salivary flow, but an unchanged glucose excretion rate were recorded when comparing stimulated saliva to unstimulated saliva. In diabetic patients, an increase in salivary flow with unchanged salivary glucose concentration and glucose excretion rate were observed under the same experimental conditions. Salivary glucose concentration and excretion were much higher in diabetic patients than in control subjects, whether in unstimulated or stimulated saliva. No significant correlation between glycemia and either glucose concentration or glucose excretion rate was found in the diabetic patients, whether in unstimulated or stimulated saliva. In the latter patients, as compared to control subjects, the relative magnitude of the increase in saliva glucose concentration was comparable, however, to that of blood glucose concentration. The relationship between these two variables was also documented in normal subjects and diabetic patients undergoing an oral glucose tolerance test.