BioMed Research International / 2009 / Article / Tab 1

Research Article

Inhibitory Effect of Flavonoids on the Efflux of 𝑁 -Acetyl 5-Aminosalicylic Acid Intracellularly Formed in Caco-2 Cells

Table 1

The effect of flavonols and transporter inhibitors on the apical and basolateral efflux of N-acetyl 5-aminosalicylic acid in Caco-2 cells. Caco-2 cells grown in Transwells were incubated with 200  M 5-ASA for 1, 2, and 4 hours in the presence of flavonols and transporter inhibitors at the concentration of 100  M. Api: apical efflux of 5-AcASA, Baso: basolateral efflux of 5-AcASA. Each value represents the mean SD of four to five experiments.

ControlFisetinQuercetinMorinMK571 Quinidine

1hrApi (nmol) ** ** **
Baso (nmol) ** ** ** **
Api/Baso ** ** ** **

2hrApi (nmol) ** ** **
Baso (nmol) ** ** ** **
Api/Baso ** ** ** **

4hrApi (nmol) ** ** **
Baso (nmol) ** ** * **
Api/Baso ** ** ** **

Significant difference from control * , ** .

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