Inhibitory Effect of Flavonoids on the Efflux of 𝑁-Acetyl 5-Aminosalicylic Acid Intracellularly Formed in Caco-2 Cells

Table 2

The cellular accumulation percent of in N-acetyl 5-aminosalicylic acid Caco-2 cells. Caco-2 cells grown in tissue culture dishes were incubated with 200 𝜇M 5-ASA for 2 hours in the presence of flavonoids at the concentration of 100 𝜇M. Cellular accumulation percent: (cells/cells plus medium) × 100. Each value represents the mean ± SD of four to five experiments.

Flavonoids	Cellular accumulation (%)	Flavonoids	Cellular accumulation (%)
Control	5.5±0.8	7,3^′,4^′- OH flavone	38.7±4.2^**
Epicatechin	5.7±0.3	Diosmetin	41.8±2.4^**
Epigallocatechin	5.8±0.3	Fisetin	42.7±1.2^**
Taxifolin	6.9±0.6	7,4^′-OH ｆlavone	42.8±4.5^**
5-OH flavone	9.2±0.2^**	Kaempferol	43.1±0.7^**
Morin	9.9±0.3^**	Isorhamnetin	45.4±4.1^**
3-OH flavone	17.4±0.9^**	Apigenin	45.7±2.3^**
7-OH flavone	20.1±3.8^**	Geraldol	50.2±1.1^**
Galangin	21.3±3.1^**	Luteolin	50.7±3.2^**
Chrysin	31.7±3.5^**	Quercetin	52.7±2.5^**
3^′,4^′-OH flavones	36.7±3.6^**

Significant differences from control *P < .05, ^**P < .01.