Investigating Topological and Functional Features of Multimodular Proteins

Table 2

Statistics for the most significant GO terms based on GO biological process. Module frequency decreases from left to right, and the last column contains a group of proteins that occur in only one module or are not present in any of the modules.

Module frequency	≥1.9	≥1.7	≥1.4	≥1.2	>1	≤1
[#] proteins	[50]	[100]	[150]	[200]	[250]	[250]
GO biological process	GO term frequency
	𝑃 value
Ribonucleoprotein complex biogenesis and assembly (5.5%)	42%	36%	41%	40%	41%	16%
	9.3⋅10^−18	3.2⋅10^−18	4.9⋅10^−37	1.9⋅10^−47	3.9⋅10^−64	1.1⋅10^−06
Cellular component organization and biogenesis (30%)	70%	62%	65%	65%	66%	56%
	1.7⋅10^−06	1.2⋅10^−08	1.0⋅10^−16	2.2⋅10^−22	1.9⋅10^−29	3.9⋅10^−55
Organelle organization and biogenesis (17.8%)	50%	45%	51%	50%	53%	35%
	5.8⋅10^−05	1.0⋅10^−07	2.1⋅10^−18	3.1⋅10^−23	2.1⋅10^−35	2.2⋅10^−08
RNA metabolic process (14.2%)	44%	48%	46%	45%	46%	32%
	8.9⋅10^−05	1.8⋅10^−13	1.3⋅10^−18	5.9⋅10^−24	1.3⋅10^−31	1.1⋅10^−10
Primary metabolic process (44%)	74%	79%	79%	81%	80%	78%
	4.7⋅10^−03	2.1⋅10^−10	1.1⋅10^−15	8.7⋅10^−25	2.5⋅10^−30	3.8⋅10^−25