Investigating Topological and Functional Features of Multimodular Proteins

Table 6

Annotation statistics for multimodular proteins of different module frequency versus single-modular proteins from Yeast CORE data set. Statistics for the most significant annotation terms of the multimodular proteins with varying occurrences intervals, compared to the corresponding statistics for single-modular proteins (CORE data set).

Module frequency	≥1.9	≥1.6	≥1.4	≥1.3	≥1.3	≥1.2	≥1.2	≥1.1	≥1.1	=1
No. proteins	50	100	150	200	250	300	350	400	450	450
GO biological process	GO term frequency
	𝑃 value
GO: 0016043 (30%) cellular component organization and biogenesis (30%)	82%	77%	76%	78%	75%	74%	73%	71%	72.7%	66%
	1.3⋅10^−11	1.1⋅10^−19	6.2⋅10^−29	5.4⋅10^−42	4.5⋅10^−47	3.2⋅10^−54	1.0⋅10^−60	1.5⋅10^−66	4.7⋅10^−80	2.1⋅10^−57
GO: 0006996 (17.8%) organelle organization and biogenesis (17.8%)	60%	53%	49%	51%	47%	46%	46%	44%	46%	43%
	1.2⋅10^−08	5.8⋅10^−13	3.0⋅10^−16	7.4⋅10^−24	9.3⋅10^−25	2.9⋅10^−27	4.9⋅10^−33	7.2⋅10^−34	1.3⋅10^−43	4.5⋅10^−36
GO: 0043283 (30.2%) biopolymer metabolic process (30.2%)	66%	68%	63%	62%	58%	58%	59%	59%	59%	57%
	7.2⋅10^−05	2.8⋅10^−12	1.8⋅10^−14	1.3⋅10^−17	1.4⋅10^−17	6.0⋅10^−21	3.5⋅10^−28	1.2⋅10^−31	2.4⋅10^−36	2.3⋅10^−30
GO: 0006139 (20.7%) nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (20.7%)	54%	52%	47%	49%	47%	46%	47%	47%	47%	45%
	8.3⋅10^−05	1.8⋅10^−09	1.1⋅10^−10	4.3⋅10^−16	3.9⋅10^−18	2.1⋅10^−21	7.5⋅10^−26	2.2⋅10^−30	5.4⋅10^−35	4.9⋅10^−31
GO: 0016070 (14.2%) metabolic process (14.2%)	42%	40%	37%	39%	36%	36%	37%	37%	37%	34%
	5.6⋅10^−04	8.0⋅10^−08	2.1⋅10^−09	3.5⋅10^−15	9.2⋅10^−16	6.7⋅10^−20	6.7⋅10^−26	2.0⋅10^−28	3.2⋅10^−32	8.9⋅10^−25
GO: 0044238 (44.0%) primary metabolic process (44.0%)		74%	70%	69%	68%	68%	69%	69%	68%	67%
		4.6⋅10^−07	4.6⋅10^−08	8.4⋅10^−10	4.7⋅10^−12	2.3⋅10^−14	1.8⋅10^−19	8.0⋅10^−22	3.1⋅10^−24	5.0⋅10^−21