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Journal of Biomedicine and Biotechnology
Volume 2009, Article ID 612805, 6 pages
http://dx.doi.org/10.1155/2009/612805
Research Article

Antioxidant and Anticancer Activities of Wampee (Clausena lansium (Lour.) Skeels) Peel

1Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
2Biotechnological Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
3Department of Food Science & Human Nutrition, Clemson University, Clemson, SC 29634, USA

Received 5 March 2009; Revised 17 May 2009; Accepted 8 June 2009

Academic Editor: Vickram Ramkumar

Copyright © 2009 K. Nagendra Prasad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antioxidant activities of wampee peel extracts using five different solvents (ethanol, hexane, ethyl acetate, butanol and water) were determined by using in-vitro antioxidant models including total antioxidant capability, 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power, and superoxide scavenging activity. Ethyl acetate fraction (EAF) exhibited the highest antioxidant activity compared to other fractions, even higher than synthetic antioxidant butylated hydroxyl toluene (BHT). In addition, the EAF exhibited strong anticancer activities against human gastric carcinoma (SGC-7901), human hepatocellular liver carcinoma (HepG-2) and human lung adenocarcinoma (A-549) cancer cell lines, higher than cisplatin, a conventional anticancer drug. The total phenolic content of wampee fraction was positively correlated with the antioxidant activity. This is the first report on the antioxidant and anticancer activities of the wampee peel extract. Thus, wampee peel can be used potentially as a readily accessible source of natural antioxidants and a possible pharmaceutical supplement.