TIS11 Family Proteins and Their Roles in Posttranscriptional Gene Regulation

Table 1

Human TIS11 family members and reported mRNA targets of the TIS11 family.

Gene	Alternative names	Chromosomal location	Reported mRNA targets	reference	mechanism
TIS11	ZFP36, TTP, Nup475, GOS24	19q13.1	TNF *	[8]	mRNA stability
			GM-CSF	[15]	mRNA stability
			IL-3	[16]	mRNA stability
			IL-6	[17]	mRNA stability
			cyclooxygenase	[18]	mRNA stability
			PAI type 2	[19]	mRNA stability
			Pitx2	[20]	mRNA stability
			TIS11	[14]	mRNA stability
			IL-2	[21]	mRNA stability
			1,4galactosyltransferase	[22]	mRNA stability
			IL-12	[23]	?
			Ccl2	[24]	mRNA stability
			Ccl3	[24]	mRNA stability
			c-myc	[25]	mRNA stability
			cyclin D1	[25]	mRNA stability
			Fos	[26]	mRNA stability
			Ier3	[27]	mRNA stability
			Genome analysis 250 mRNAs	[27]	mRNA stability
			MIP-2	[23]	?
			p21	[26]	mRNA stability
			E47	[28]	mRNA stability
			VEGF	[29]	mRNA stability
			IL-10	[30]	mRNA stability
			Genome analysis 137 mRNAs	[30]	mRNA stability
			polo-like kinase 3	[31]	mRNA stability
TIS11b	ZFP36L1, Berg36, ERF-1, BRF-1	14q22-24	TNF	[32]	mRNA stability
			GMCSF	[33]	mRNA stability
			IL-3	[34]	mRNA stability
			VEGF	[35]	mRNA stability
			c-IAP2	[36]	mRNA stability
			VEGF	[37]	translation
			STAR	[38]	mRNA stability
TIS11d	ZFP36L2, ERF-2, BRF-2	2p22.3-p21	TNF	[32]	mRNA stability
			GM-CSF	[33]	mRNA stability
			IL-3	[33]	mRNA stability

*Targets in bold confirmed in cells derived from knockout animals are so-called “physiological" targets.