Review Article
MicroRNA Implications across Neurodevelopment and Neuropathology
Table 1
miRNAs involved in neurodevelopment.
| miRNA | Species | Target | Function | Reference number |
| miR-iab-4-5p | Drosophila | UBX | Regulation of Hox gene involved in the development of halters | [34] | miR10a | Human | HOXA1 | Downregulation of HOXA1 geneExpression | [35] | lsy-6 | C. elegans | Cog-1 | Required to specify ASEL sensory neuron identity | [36, 37] | miR-273 | C. elegans | Die-1 | Expressed in ASER; suppresses ASEL identity | [36, 38] | miR-196 | Rodents | HOXB8 | Downregulation of HOXC8, HOXD8 and HOXA7 | [39] | miR-124 | Rodents | SCP1 | Neural induction in the spinal cord of developing embryos | [40] | miR-124 | Rodents | SOX9 | Regulation of the neurogenesis in the SVZ stem cell niche and neurite outgrowth in neuronal differentiation | [41] | miR-132 | Rodents | P250GAP | Regulation of the neuronal morphogenesis and circadian clock | [42, 43] | miR-219 | Rodents | SCOP | Regulation of the circadian period length | [36, 43] | miR-133b | Rodents | Pitx3 | Regulation of the maturation of midbrain dopaminergic neurons | [44] | miR-134 | Rodents | LimK1 | Modulation of the size of dendritic spines | [45] |
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