A New Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Bisoprolol in Human Plasma Samples

Table 3

Evaluation of interday precision and accuracy for bisoprolol spiked quality control samples.

Cth = 3 ng/mL			Cth = 25 ng/mL		Cth = 75 ng/mL
	Cexp (ng/mL)	Accuracy (%)	Cexp (ng/mL)	Accuracy (%)	Cexp (ng/mL)	Accuracy (%)
(1)	3.015	101.860	24.331	98.586	70.921	95.788
(2)	2.879	97.276	23.332	94.539	77.073	104.097
(3)	3.257	110.048	23.109	93.636	77.932	105.256
(4)	2.964	100.136	24.013	97.297	70.590	95.340
(5)	2.943	99.439	28.411	115.117	75.582	102.083
(6)	3.152	106.480	24.910	100.933	74.865	101.115
Mean	3.035	102.540	24.684	100.018	74.494	100.613
SD	0.142		1.940		3.092
CV %	4.686		7.860		4.151
		Acceptance criteria
		67% Total QCs must be 100±15% nominal values
		50% QCs per level must be 100±15% nominal values
		Mean % nominal 100±15%
		CV (%) ≤ 15%