Oxidative Imbalance in HIV-1 Infected Patients Treated with Antiretroviral Therapy

Table 1

Clinical data of HIV patients and controls.

	Controls	HIV-1-treated	HIV-1-untreated	𝑃
Number	46	86	30
Age (years)	39.5 ± 11.4	40.9 ± 8.1	35.9 ± 7.9	.038^∗
Age range	21–61	16–65	21–45
Female/male	21/25	39/47	14/16	.992^∗
Current smokers	20	57	14	.021^§
Cigarettes daily	23.1 ± 9.1	25.7 ± 9.8	21.7 ± 9.4	.290^∗
BMI	21.7 ± 1.4	22.8 ± 2.7	23.0 ± 2.2	.017^∗
Cholesterolemia (mg/dL)	183.0 ± 27.4	195.4 ± 39.4	164.7 ± 25.4	.000^∗
Triglyceridemia (mg/dL)	84.7 ± 39.8	181.1± 179.8	90.5 ± 38.9	.000^∗
Glycemia (mg/dL)	88.4 ± 10.3	89.7 ± 19.2	90.5 ± 10.8	.836^∗
ALT (UI/L)	21.1 ± 8.2	46.5 ± 38.9	40.13 ± 36.5	.000^∗
HCV positive	0	39	13
HBV positive	0	1	0
HCV + HDV positive	0	4	1
HAART-PI	—	49	—
HAART-NNRTI	—	33	—
HAART-PI + NNRTI	—	4	—
CD4 T-cell count (cells/mL)	nd	554.4 ± 279.2	528.9 ± 119.5	.629^∗
CD4 T-cell count ≥500cells/mL	—	46	16	.864^§
CD4 T-cell count 499–200 cells/mL	—	32	14	.693^§
CD4 T-cell count <200cells/mL	—	8	0	.220^§
HIV-RNA level (log10cp/mL)	nd	2.2 ± 0.8	4.1 ± 0.4	.000^∗
HIV-RNA <400cp/mL	—	69	0

Data are expressed as mean ± SD.
^∗Calculated by One-Way ANOVA.
^§Calculated by 𝜒².