Genetic Polymorphisms in the EGFR (R521K) and Estrogen Receptor (T594T) Genes, EGFR and ErbB-2 Protein Expression, and Breast Cancer Risk in Tunisia

Table 3

Association between EGFR and ESR1 genotype with EGFR, HER2, ER, PR, and BCL2 protein expression and clinical parameters.

Parameter	Genotype counts				Genotype counts
	EGFR R521K				ESR1 T594T
	AA	AG	GG	Chi-square	AA	AG	GG	Chi-square
				𝑃-value				𝑃-value
Tumour size
≤2 cm	2	5	17	1.172	0	6	17	1.077
>2 cm	9	37	70	.557	5	29	78	.584
Lymph-node
Negative	6	9	37	7.022	3	16	31	3.629
Positive	6	35	51	.030	2	19	68	.163
Tumour grade
SBR I/II	9	31	45	9.103	3	18	60	3.080
SBR III	1	8	35	.011	0	14	28	.214
Estrogen receptor 1
Negative −	5	12	26	1.035	2	8	32	1.640
Positive +	6	29	54	.596	2	24	59	.440
Progesterone receptor
Negative −	4	12	39	3.575	2	12	41	.717
Positive +	7	30	46	.167	3	22	53	.699
BCL2-protein
Negative −	1	7	18	1.502	1	7	18	.6
Positive +	7	16	35	.472	1	13	44	.741
HER2-protein
Negative −	3	13	24	.581	0	16	24	9.428
Positive +	6	15	36	.748	2	8	47	.009
EGFR-protein
Negative −	7	12	32	3.112	2	13	36	1.631
Positive +	1	11	21	.211	0	7	26	.442